SCHEMBL10955950

SCHEMBL10955950

CCN1CCc2cc(O)cc3c2C1Cc1ccc(O)c(O)c1-3

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.85
MAPK1 P28482 3/20 0.85
ALDH1A1 P00352 3/20 0.85
RGS12 O14924 2/20 0.85
CYP1A2 P05177 2/20 0.85
NFKB1 P19838 2/20 0.85
THPO P40225 2/20 0.85
MTOR P42345 2/20 0.85
GNAI1 P63096 2/20 0.85
HIF1A Q16665 2/20 0.85
HSD17B10 Q99714 2/20 0.85
TP53 P04637 1/20 0.85
CYP2D6 P10635 1/20 0.85
CYP2C9 P11712 1/20 0.85
KDM4E B2RXH2 2/20 0.83
LMNA P02545 2/20 0.83
HPGD P15428 2/20 0.83
PMP22 Q01453 2/20 0.83
KMT2A Q03164 2/20 0.83
NPSR1 Q6W5P4 2/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29380552 0.92 MAPT (1.00) MAPTMAPK1ALDH1A1RGS12CYP1A2
SCHEMBL1325960 0.92 MAPT (1.00) MAPTMAPK1ALDH1A1RGS12CYP1A2
SCHEMBL1325958 0.92 MAPT (1.00) MAPTMAPK1ALDH1A1RGS12CYP1A2
Bromide SCHEMBL1325230 0.91 MAPT (1.00) MAPTMAPK1ALDH1A1RGS12CYP1A2
Bromide SCHEMBL1325232 0.91 MAPT (1.00) MAPTMAPK1ALDH1A1RGS12CYP1A2
SCHEMBL18968269 0.86 DRD3 (0.82) MAPTMAPK1ALDH1A1RGS12CYP1A2
SCHEMBL10956263 0.85 MAPT (0.75) MAPTMAPK1ALDH1A1RGS12CYP1A2
SCHEMBL10958146 0.85 MAPT (0.73) MAPTMAPK1ALDH1A1RGS12CYP1A2
SCHEMBL15170119 0.85 DRD3 (0.87) DRD1DRD2DRD3
SCHEMBL14161595 0.85 MAPT (0.83) MAPTMAPK1ALDH1A1RGS12CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0040074-B1 N-SUBSTITUTED APORPHINES, A METHOD OF INDUCING EMESIS AND A METHOD OF CONTROLLING PSYCHOSIS UTILISING THE SAME NORTHEASTERN UNIVERSITY (US) 1985-07-31 EP claimed
EP-0040074-A1 N-substituted aporphines, a method of inducing emesis and a method of controlling psychosis utilising the same NORTHEASTERN UNIVERSITY (US) 1981-11-18 EP claimed