Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | RGS12 | O14924 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 3/20 | 1.00 |
| ▸ | THPO | P40225 | 3/20 | 1.00 |
| ▸ | MTOR | P42345 | 3/20 | 1.00 |
| ▸ | GNAI1 | P63096 | 3/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.98 |
| ▸ | LMNA | P02545 | 4/20 | 0.98 |
| ▸ | HPGD | P15428 | 4/20 | 0.98 |
| ▸ | PMP22 | Q01453 | 4/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.98 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1325958 | 1.00 | MAPT (1.00) | MAPTMAPK1ALDH1A1RGS12CYP1A2 | |
| SCHEMBL29380552 | 1.00 | MAPT (1.00) | MAPTMAPK1ALDH1A1RGS12CYP1A2 | |
| Bromide SCHEMBL1325232 | 0.99 | MAPT (1.00) | MAPTMAPK1ALDH1A1RGS12CYP1A2 | |
| Bromide SCHEMBL1325230 | 0.99 | MAPT (1.00) | MAPTMAPK1ALDH1A1RGS12CYP1A2 | |
| SCHEMBL10955950 | 0.92 | MAPT (0.85) | MAPTMAPK1ALDH1A1RGS12CYP1A2 | |
| SCHEMBL12878037 | 0.90 | DRD1 (1.00) | MAPTMAPK1ALDH1A1RGS12CYP1A2 | |
| SCHEMBL12284387 | 0.89 | DRD3 (1.00) | MAPTMAPK1ALDH1A1RGS12CYP1A2 | |
| SCHEMBL14535819 | 0.89 | DRD3 (1.00) | MAPTMAPK1ALDH1A1RGS12CYP1A2 | |
| SCHEMBL12284193 | 0.87 | DRD3 (1.00) | MAPTMAPK1ALDH1A1RGS12CYP1A2 | |
| SCHEMBL29387586 | 0.87 | DRD3 (1.00) | MAPTMAPK1ALDH1A1RGS12CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220125379-A1 | METHODS FOR IDENTIFYING RESPONDERS TO DOPAMINERGIC NEURONAL ENHANCING THERAPIES FOR THE TREATMENT OF ELEVATED HEART RATE AND METABOLIC OR CARDIOVASCULAR CONDITIONS | VEROSCIENCE LLC (US) | 2022-04-28 | — | — | US | disclosed |
| US-20220079899-A1 | COMPOSITIONS AND METHODS FOR TREATING OCULAR CONDITIONS | UNITED STATES GOVERNMENT | 2022-03-17 | — | — | US | disclosed |
| US-20170340271-A1 | METHODS FOR IDENTIFYING RESPONDERS TO DOPAMINERGIC NEURONAL ENHANCING THERAPIES FOR THE TREATMENT OF ELEVATED HEART RATE AND METABOLIC OR CARDIOVASCULAR CONDITIONS | VEROSCIENCE LLC (US) | 2017-11-30 | — | — | US | disclosed |
| US-20160068569-A1 | STRUCTURE-BASED PEPTIDE INHIBITORS OF P53 AGGREGATION AS A NEW APPROACH TO CANCER THERAPEUTICS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-03-10 | — | — | US | disclosed |
| US-20140275224-A1 | CYTOSINE DEAMINASE MODULATORS FOR ENHANCEMENT OF DNA TRANSFECTION | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140275224-A1 | CYTOSINE DEAMINASE MODULATORS FOR ENHANCEMENT OF DNA TRANSFECTION | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2014-09-18 | — | — | US | disclosed |
| WO-2013074059-A2 | CYTOSINE DEAMINASE MODULATORS FOR ENHANCEMENT OF DNA TRANSFECTION | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2013-05-23 | — | — | WO | disclosed |
| US-8058243-B2 | Method for treating a brain cancer with ifenprodil | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2011-11-15 | — | — | US | disclosed |
| US-20110218158-A1 | DNA CYTOSINE DEAMINASE INHIBITORS | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2011-09-08 | — | — | US | disclosed |
| US-20110218158-A1 | DNA CYTOSINE DEAMINASE INHIBITORS | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2011-09-08 | — | — | US | disclosed |
| WO-2010033986-A2 | DNA CYTOSINE DEAMINASE INHIBITORS | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220079899-A1 | COMPOSITIONS AND METHODS FOR TREATING OCULAR CONDITIONS | ENPP1, ENPP3, ENPP2 | MAPT 3025/4885MAPK1 2088/4885ALDH1A1 1417/4885 |
| US-20110218158-A1 | DNA CYTOSINE DEAMINASE INHIBITORS | DCTD, APOBEC3A, UNG | MAPT 4260/4885MAPK1 4366/4885ALDH1A1 795/4885 |
| US-20160068569-A1 | STRUCTURE-BASED PEPTIDE INHIBITORS OF P53 AGGREGATION AS A NEW APPROACH TO CANCER THERAPEUTICS | TP53, TP53BP1, API5 | MAPT 32/4885MAPK1 2475/4885ALDH1A1 4635/4885 |
| US-20140275224-A1 | CYTOSINE DEAMINASE MODULATORS FOR ENHANCEMENT OF DNA TRANSFECTION | CDA, DCTD, ADA | MAPT 4829/4885MAPK1 4614/4885ALDH1A1 2191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.