Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1096462 | 0.99 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPTLMNAHTTKDM4E | |
| SCHEMBL1095120 | 0.85 | SCD (0.59) | SMN1; SMN2MAPTLMNAKDM4E | |
| SCHEMBL1094940 | 0.85 | SCD (0.59) | SMN1; SMN2MAPTLMNAKDM4E | |
| SCHEMBL1095707 | 0.84 | LMNA (0.44) | SMN1; SMN2LMNAHTTKDM4EL3MBTL1 | |
| SCHEMBL1094544 | 0.83 | LMNA (0.44) | SMN1; SMN2LMNAHTTKDM4EL3MBTL1 | |
| SCHEMBL1095070 | 0.81 | HSD17B10 (0.53) | SMN1; SMN2MAPTLMNAKDM4EL3MBTL1 | |
| SCHEMBL2429706 | 0.80 | SCD (0.58) | SMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL1096540 | 0.80 | HSD17B10 (0.52) | SMN1; SMN2MAPTLMNAKDM4EL3MBTL1 | |
| SCHEMBL3667645 | 0.80 | SCD (0.57) | SMN1; SMN2MAPTLMNANPC1RAB9A | |
| SCHEMBL3671799 | 0.79 | SCD (0.56) | SMN1; SMN2MAPTLMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153636-B2 | Pyridyl derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2012-04-10 | — | — | US | disclosed |
| EP-2316825-A1 | Pyridyl derivatives and their use as therapeutic agents | Xenon Pharmaceuticals Inc. (CA) | 2011-05-04 | — | — | EP | disclosed |