Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 9/20 | 0.61 |
| ▸ | DBF4 | Q9UBU7 | 9/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10958521 | 0.82 | CDC7 (0.46) | CDC7DBF4KMT2AMEN1KDM4E | |
| SCHEMBL10953772 | 0.81 | TBK1 (0.59) | CDC7DBF4KMT2AMEN1KDM4E | |
| SCHEMBL10958051 | 0.81 | CDC7 (0.57) | CDC7DBF4KMT2AKDM4EALDH1A1 | |
| SCHEMBL10958203 | 0.80 | CYP19A1 (0.42) | CDC7DBF4IKBKETBK1 | |
| SCHEMBL22460192 | 0.77 | CDC7 (0.67) | CDC7DBF4KMT2AMEN1KDM4E | |
| SCHEMBL10956261 | 0.76 | TBK1 (0.50) | CDC7DBF4KMT2AMEN1KDM4E | |
| SCHEMBL11116425 | 0.72 | CDC7 (0.56) | CDC7DBF4KMT2AMEN1KDM4E | |
| SCHEMBL1460034 | 0.72 | CDC7 (0.56) | CDC7DBF4 | |
| SCHEMBL13040000 | 0.71 | MAP4K1 (0.36) | CDC7DBF4ALDH1A1POLBNPC1 | |
| SCHEMBL10053593 | 0.71 | CDC7 (0.51) | CDC7DBF4KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4528291-A | 2-(4'-Pyridinyl)-thiazole compounds and their use in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-07-09 | — | — | US | disclosed |
| EP-0097323-A2 | 2-(4-Pyridyl)-thiazole derivatives | SCHERING CORPORATION (US) | 1984-01-04 | — | — | EP | disclosed |