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TBK1

Serine/threonine-protein kinase TBK1 · Q9UHD2 · TBK1 on Sugi Atlas →

76,134 patent compounds predicted against TBK1, 38,716 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Amlexanox Amlexanox (SCHEMBL29642) 1.00 20/20
Nedocromil Nedocromil (SCHEMBL371456) 0.59 20/20
SCHEMBL462157 SCHEMBL462157 0.56 14/20
SCHEMBL462158 SCHEMBL462158 0.56 14/20
SCHEMBL807541 SCHEMBL807541 0.45 14/20
SCHEMBL465696 SCHEMBL465696 0.51 13/20
SCHEMBL857243 SCHEMBL857243 0.47 12/20
SCHEMBL459048 SCHEMBL459048 0.73 11/20
SCHEMBL461618 SCHEMBL461618 0.56 11/20
SCHEMBL389595 SCHEMBL389595 0.51 11/20
SCHEMBL739077 SCHEMBL739077 0.45 11/20
SCHEMBL31814 SCHEMBL31814 0.38 11/20
SCHEMBL434250 SCHEMBL434250 0.58 10/20
SCHEMBL434285 SCHEMBL434285 0.58 10/20
SCHEMBL433112 SCHEMBL433112 0.55 9/20
SCHEMBL433250 SCHEMBL433250 0.55 9/20
SCHEMBL434303 SCHEMBL434303 0.54 9/20
SCHEMBL434757 SCHEMBL434757 0.54 9/20
SCHEMBL807926 SCHEMBL807926 0.43 9/20
SCHEMBL432386 SCHEMBL432386 0.55 8/20

Clinical trials — most relevant to TBK1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The Efficacy and Safety of Deucravacitinib in Takayasu's Arteritis PHASE4NOT_YET_RECRUITING
Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized) PHASE3UNKNOWN
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
Azithromycin Plus Hydroxychloroquine for COVID-19 Infection PHASE3WITHDRAWN
Efficacy of Amlexanox vs. Placebo in Type 2 Diabetic Patients PHASE2COMPLETED
Efficacy and Safety of Drug Combination Therapy of Isotretinoin and Some Antifungal Drugs as A Potential Aerosol Therapy for COVID-19 : An Innovative Therapeutic Approach COVID-19 PHASE2UNKNOWN
Dendritic Cells for Immunotherapy of Metastatic Endometrial Cancer Patients PHASE2COMPLETED
Evaluating Safety, Pharmacokinetics and Clinical Benefit of Silmitasertib (CX-4945) in Subjects With Moderate COVID-19 PHASE2COMPLETED
I/II Phase Study Evaluating M1774 in Combination With Fulvestrant in HR+ and HER2- Advanced Breast Cancers PHASE1/PHASE2NOT_YET_RECRUITING
Single Arm Trial of Tumor-Treating Fields in Combination With Nivolumab and Ipilimumab in Metastatic Uveal Melanoma PHASE1COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
ADAR1 Expression Level in Rectal Cancer nanRECRUITING
Ccf mtDNA as a Neurodegenerative Biomarker nanUNKNOWN
Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still'S-like Diseases, and Other Undifferentiated Autoinflammatory Diseases) nanRECRUITING
RNA Cloning and Visualization in Human Atherosclerosis nanCOMPLETED
Exploring Novel Biomarkers of ICU-AW in Mechanically Ventilated Children at the Molecular Level nanENROLLING_BY_INVITATION
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside nanUNKNOWN
Gene Expression Of Suppressor Of Cytokines in In Cutaneous Warts nanCOMPLETED
Microbiota in COVID-19 Patients for Future Therapeutic and Preventive Approaches nanUNKNOWN
Novel Biomarkers in Inflammatory Bowel Disease nanCOMPLETED
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence nanNOT_YET_RECRUITING
Genetic Variation in TRAF3IP2 (rs13190932) nanRECRUITING
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Deep Phenotyping of Cutaneous Lupus Erythematosus nanUNKNOWN
Fasting, Exercise, and Diet to Activate Autophagy in Depression nanNOT_YET_RECRUITING
A Dose-escalation Trial of Stereotactic Ablative Body Radiotherapy for Non-spine Bone & Lymph Node Oligometastates nanCOMPLETED
Immune Interactions in Severe Asthma nanCOMPLETED
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients nanCOMPLETED
Card14gene (rs34367357 ) Polymorphism in Egyptian Psoriatic and Psoriatic Arthritis Patient nanRECRUITING
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP) nanNOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a TBK1 binder may also engage these)

ProteinNameSimilarity
Q9WUN2 — 1.000 Q9WUN2 →
Q6DFJ6 — 1.000 Q6DFJ6 →
Q9R0T8 — 0.986 Q9R0T8 →
MAP3K5 Mitogen-activated protein kinase kinase kinase 5 0.985 landscape →
O35099 — 0.984 O35099 →
PLK2 Serine/threonine-protein kinase PLK2 0.984 landscape →
Q21029 — 0.984 Q21029 →
Q5R4L1 — 0.982 Q5R4L1 →
P62205 — 0.982 P62205 →
Q9R012 — 0.981 Q9R012 →
Q921C3 — 0.981 Q921C3 →
IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon 0.981 landscape →
F1ND48 — 0.981 F1ND48 →
F4IVI0 — 0.980 F4IVI0 →
Q6DDI6 — 0.980 Q6DDI6 →
Q6DD21 — 0.980 Q6DD21 →
Q8N1G2 — 0.980 Q8N1G2 →
Q9UPM8 — 0.979 Q9UPM8 →
Q95JW3 — 0.979 Q95JW3 →
P53351 — 0.979 P53351 →
Q8BPM2 — 0.979 Q8BPM2 →
MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 0.979 landscape →
Q91821 — 0.979 Q91821 →
Q8VDY4 — 0.979 Q8VDY4 →
Q5R981 — 0.978 Q5R981 →
A2AQW0 — 0.978 A2AQW0 →
PTK2 Focal adhesion kinase 1 0.978 landscape →
Q28GW8 — 0.978 Q28GW8 →
Q9DBC3 — 0.978 Q9DBC3 →
O02697 — 0.978 O02697 →