Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.72 |
| ▸ | CNR1 | P21554 | 1/20 | 0.72 |
| ▸ | HTR2B | P41595 | 1/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Minaprine SCHEMBL49371 | 0.84 | ACHE (1.00) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| Minaprine SCHEMBL124094 | 0.83 | CYP3A4 (1.00) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| Minaprine SCHEMBL124092 | 0.83 | CYP3A4 (1.00) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| Minaprine SCHEMBL124093 | 0.82 | ACHE (0.95) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| Moxiraprine SCHEMBL635650 | 0.82 | ACHE (0.80) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| SCHEMBL10958038 | 0.80 | ACHE (0.69) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| SCHEMBL10748868 | 0.80 | ACHE (0.77) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| SCHEMBL10744195 | 0.80 | ACHE (0.78) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| SCHEMBL10958687 | 0.78 | ACHE (0.43) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| Morpholine SCHEMBL10958702 | 0.77 | ACHE (0.43) | ACHELMNACYP3A4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4524070-A | Aminated derivatives of pyridazine substituted in 6 position by a heterocycle or an alicycle and compositions, said derivatives being active on the central nervous system | SANOFI (FR) | 1985-06-18 | — | — | US | claimed |
| US-4524070-A | Aminated derivatives of pyridazine substituted in 6 position by a heterocycle or an alicycle and compositions, said derivatives being active on the central nervous system | SANOFI (FR) | 1985-06-18 | — | — | US | disclosed |