Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.50 |
| ▸ | PDE4A | P27815 | 9/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Domipizone SCHEMBL1814940 | 0.86 | PDE4B (0.69) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL10963223 | 0.78 | GPR119 (0.60) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL6934156 | 0.74 | GPR119 (0.74) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL10956557 | 0.74 | PDE3B (0.48) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL11014998 | 0.73 | GPR119 (0.48) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL6934765 | 0.72 | GPR119 (0.61) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL11013347 | 0.71 | PDE3B (0.45) | PDE3BPDE3AGPR119MAPTSMN1; SMN2 | |
| SCHEMBL10961794 | 0.71 | GPR119 (0.54) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL10961439 | 0.71 | PDE3B (0.46) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL10961856 | 0.71 | GPR119 (0.58) | PDE3BPDE3AGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129791-A2 | Tetrahydropyridazinone derivatives, process for their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1985-01-02 | — | — | EP | disclosed |