Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 4/20 | 0.63 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL10952781 | 0.98 | CDK5 (0.62) | CDK5CDK5R1HPGDROCK1LMNA | |
| SCHEMBL11507528 | 0.87 | CDK5 (0.62) | CDK5CDK5R1HPGDMAPTCCNA2 | |
| SCHEMBL5341105 | 0.87 | CDK5 (0.81) | CDK5CDK5R1HPGDROCK1LMNA | |
| SCHEMBL12803498 | 0.85 | CDK5 (0.69) | CDK5CDK5R1HPGDROCK1LMNA | |
| SCHEMBL7056328 | 0.84 | CDK5 (0.68) | CDK5CDK5R1HPGDROCK1LMNA | |
| SCHEMBL11507986 | 0.84 | RAB9A (0.57) | CDK5CDK5R1LMNAMAPTCCNA2 | |
| SCHEMBL5689927 | 0.84 | CDK5 (0.63) | CDK5CDK5R1HPGDROCK1LMNA | |
| SCHEMBL3258037 | 0.80 | CDK5 (0.55) | CDK5CDK5R1HPGDROCK1LMNA | |
| SCHEMBL5787044 | 0.79 | CDK5 (0.54) | CDK5CDK5R1HPGDROCK1LMNA | |
| SCHEMBL14558329 | 0.79 | CDK5 (0.62) | CDK5CDK5R1HPGDROCK1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4528291-A | 2-(4'-Pyridinyl)-thiazole compounds and their use in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-07-09 | — | — | US | disclosed |
| EP-0097323-A2 | 2-(4-Pyridyl)-thiazole derivatives | SCHERING CORPORATION (US) | 1984-01-04 | — | — | EP | disclosed |