⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17487350 | 0.78 | — | — | |
| SCHEMBL5717354 | 0.75 | — | — | |
| SCHEMBL14559243 | 0.69 | — | — | |
| SCHEMBL295752 | 0.69 | — | — | |
| SCHEMBL2005096 | 0.69 | — | — | |
| SCHEMBL29090572 | 0.69 | ALDH1A1 (0.33) | — | |
| SCHEMBL29384820 | 0.68 | LCK (0.43) | — | |
| SCHEMBL21585899 | 0.68 | DPP4 (0.30) | — | |
| SCHEMBL28564537 | 0.67 | — | — | |
| SCHEMBL28564535 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1200717-A | Process for preparing 4-bromo-1,1-difluorbut-1-ene and 2,4-dibromo-1,1,1-trifluorobutane | ZENECA LTD (GB) | 1998-12-02 | — | — | CN | claimed |
| EP-4691465-A2 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | The Trustees of Columbia University in the City of New York (US) | 2026-02-11 | — | — | EP | disclosed |
| EP-4682141-A1 | TRICYCLIC COMPOUND | ONO Pharmaceutical Co., Ltd. (JP) | 2026-01-21 | — | — | EP | disclosed |
| EP-4036094-B1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | UNIV COLUMBIA (US) | 2025-12-24 | — | — | EP | disclosed |
| US-20250320218-A1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2025-10-16 | — | — | US | disclosed |
| US-12404277-B2 | Substituted 4-phenylpiperidines, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2025-09-02 | — | — | US | disclosed |
| WO-2025076523-A1 | RAS INHIBITORS AND METHODS OF USE THEREOF | KESTREL THERAPEUTICS, INC. (US) | 2025-04-10 | — | — | WO | disclosed |
| EP-4512816-A2 | TLR7 AGONISTS | Primmune Therapeutics, Inc. (US) | 2025-02-26 | — | — | EP | disclosed |
| WO-2024190777-A1 | TRICYCLIC COMPOUND | 小野薬品工業株式会社 | 2024-09-19 | — | — | WO | disclosed |
| WO-2024190780-A1 | PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR KIDNEY DISEASES CONTAINING TRICYCLIC COMPOUND | 小野薬品工業株式会社 | 2024-09-19 | — | — | WO | disclosed |
| CN-106794364-A | Substituted 4-phenylpiperidines, their preparation and use | 哥伦比亚大学董事会 | 2017-05-31 | — | — | CN | disclosed |
| CN-105121426-B | Pyrrolidine GPR40 regulators | 百时美施贵宝公司 | 2017-03-29 | — | — | CN | disclosed |
| EP-3137168-A1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARAITON AND USE | The Trustees of Columbia University in the City of New York (US) | 2017-03-08 | — | — | EP | disclosed |
| US-20160368925-A1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-12-22 | — | — | US | disclosed |
| US-9434727-B2 | Substituted 4-phenylpiperidines, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-09-06 | — | — | US | disclosed |
| US-20150315197-A1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-11-05 | — | — | US | disclosed |
| WO-2015168286-A1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARAITON AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-11-05 | — | — | WO | disclosed |
| CN-1200717-A | Process for preparing 4-bromo-1,1-difluorbut-1-ene and 2,4-dibromo-1,1,1-trifluorobutane | ZENECA LTD (GB) | 1998-12-02 | — | — | CN | disclosed |
| US-4552883-A | CNS DEPRESSANTS, ANXIOLYTICS | ICI AMERICAS INC. (US) | 1985-11-12 | — | — | US | disclosed |
| EP-0096995-A2 | Pyrazolopyridine compounds | ICI AMERICAS INC. (US) | 1983-12-28 | — | — | EP | disclosed |