Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.56 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | BMP1 | P13497 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10959638 | 1.00 | METAP2 (0.56) | METAP2METAP1ALDH1A1NPSR1CYP1A2 | |
| SCHEMBL8330172 | 0.84 | METAP2 (0.53) | METAP2METAP1ALDH1A1NPSR1CYP1A2 | |
| Hydrochloric Acid SCHEMBL10523064 | 0.83 | METAP2 (0.46) | METAP2METAP1ALDH1A1MMP2ATM | |
| SCHEMBL60279 | 0.83 | METAP2 (0.56) | METAP2METAP1ALDH1A1NPSR1CYP1A2 | |
| SCHEMBL60885 | 0.83 | METAP2 (0.56) | METAP2METAP1ALDH1A1NPSR1CYP1A2 | |
| Hydrochloric Acid SCHEMBL10523043 | 0.83 | METAP2 (0.46) | METAP2METAP1ALDH1A1MMP2ATM | |
| SCHEMBL8331302 | 0.82 | METAP2 (0.51) | METAP2METAP1ALDH1A1NPSR1CYP1A2 | |
| SCHEMBL4737862 | 0.82 | METAP2 (0.45) | METAP2ALDH1A1NPSR1TSHRTHRB | |
| SCHEMBL3620878 | 0.81 | METAP2 (0.58) | METAP2METAP1ALDH1A1NPSR1CYP1A2 | |
| SCHEMBL8178506 | 0.81 | METAP2 (0.58) | METAP2METAP1ALDH1A1NPSR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4525301-A | REACTING TRIFLUOROMETHANE SULFONIC ACID DERIVATIVES WITH AMINO ACID ESTERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-06-25 | — | — | US | disclosed |