Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | SLC5A1 | P13866 | 6/20 | 0.47 |
| ▸ | SLC5A2 | P31639 | 5/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 4/20 | 0.44 |
| ▸ | CA9 | Q16790 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10964516 | 0.79 | MEN1 (0.55) | MEN1CYP3A4KMT2ATP53CYP2C9 | |
| SCHEMBL10960928 | 0.78 | SLC5A1 (0.72) | CYP3A4CYP2C9SLC5A1SLC5A2 | |
| SCHEMBL10960926 | 0.78 | SLC5A1 (0.72) | CYP3A4CYP2C9SLC5A1SLC5A2 | |
| SCHEMBL3996614 | 0.78 | CYP3A4 (0.56) | MEN1CYP3A4KMT2ATP53CYP2C9 | |
| SCHEMBL3996608 | 0.78 | CYP3A4 (0.56) | MEN1CYP3A4KMT2ATP53CYP2C9 | |
| SCHEMBL7945964 | 0.77 | CYP3A4 (0.65) | MEN1CYP3A4KMT2ATP53CYP2C9 | |
| SCHEMBL22073058 | 0.77 | CYP3A4 (0.65) | MEN1CYP3A4KMT2ATP53CYP2C9 | |
| SCHEMBL22710592 | 0.77 | CYP3A4 (0.65) | MEN1CYP3A4KMT2ATP53CYP2C9 | |
| SCHEMBL16689628 | 0.77 | CYP3A4 (0.65) | MEN1CYP3A4KMT2ATP53CYP2C9 | |
| SCHEMBL18022553 | 0.77 | CYP3A4 (0.65) | MEN1CYP3A4KMT2ATP53CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0051819-B1 | TETRA-SUBSTITUTED BENZENE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-02-13 | — | — | EP | disclosed |