Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11416338 | 0.85 | NOX1 (0.50) | NOX1MAPTTP53SMPD3KMT2A | |
| SCHEMBL10963408 | 0.85 | KDM4E (0.40) | NOX1MAPTSMPD3KMT2AMEN1 | |
| SCHEMBL10965124 | 0.83 | MAPK14 (0.47) | MAPTKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL10965783 | 0.83 | MAPK14 (0.43) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL10963611 | 0.82 | NOX1 (0.47) | NOX1MAPTTP53SMPD3KMT2A | |
| SCHEMBL11410108 | 0.82 | NOX1 (0.47) | NOX1MAPTTP53SMPD3KMT2A | |
| SCHEMBL11410897 | 0.81 | NOX1 (0.46) | NOX1MAPTTP53SMPD3KMT2A | |
| SCHEMBL11498999 | 0.81 | NOX1 (0.46) | NOX1MAPTTP53SMPD3KMT2A | |
| SCHEMBL10804559 | 0.80 | NOX1 (0.45) | NOX1MAPTTP53SMPD3KMT2A | |
| SCHEMBL10961220 | 0.80 | NOX1 (0.48) | NOX1MAPTTP53SMPD3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005545-B1 | IMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-09-18 | — | — | EP | claimed |
| US-4355039-A | Antiinflammatory-4,5-diaryl-2-substituted-thio-imidazoles and their corresponding sulfoxides and sulfones | SCHERING, AKTIENGESELLSCHAFT (DE) | 1982-10-19 | — | — | US | claimed |
| EP-0005545-A2 | Imidazole derivatives, process for their preparation and pharmaceutical compositions containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1979-11-28 | — | — | EP | claimed |
| EP-0005545-B1 | IMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-09-18 | — | — | EP | disclosed |
| US-4440776-A | ANTIARTHRITIC AGENTS; ANTIALLERGENS; BRONCHODILATOR AGENTS; SKIN DORDERS | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-04-03 | — | — | US | disclosed |
| US-4355039-A | Antiinflammatory-4,5-diaryl-2-substituted-thio-imidazoles and their corresponding sulfoxides and sulfones | SCHERING, AKTIENGESELLSCHAFT (DE) | 1982-10-19 | — | — | US | disclosed |
| US-4269847-A | ANTIALLERGENS; DERIVATIVES OF 4,5-BIS/PHENYL-2-MERCAPTO-, THIO-, S | SCHERING AKTIENGESELLSCHAFT (DE) | 1981-05-26 | — | — | US | disclosed |
| EP-0005545-A2 | Imidazole derivatives, process for their preparation and pharmaceutical compositions containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1979-11-28 | — | — | EP | disclosed |