Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.43 |
| ▸ | GCGR | P47871 | 7/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | FRK | P42685 | 2/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10963408 | 0.86 | KDM4E (0.40) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL10965783 | 0.86 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL10964800 | 0.83 | NOX1 (0.50) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL10802695 | 0.78 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL14712904 | 0.78 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11EGFR | |
| SCHEMBL5435606 | 0.69 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL10832361 | 0.69 | MAPT (0.54) | MAPK14PTGS2KDM4EALDH1A1LMNA | |
| SCHEMBL11253485 | 0.69 | MAPT (0.54) | MAPK14PTGS1PTGS2KDM4EALDH1A1 | |
| SCHEMBL10963620 | 0.69 | MAPK14 (0.87) | MAPK14MAPK13MAPK12MAPK11PTGS1 | |
| SCHEMBL10967084 | 0.69 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005545-B1 | IMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-09-18 | — | — | EP | claimed |
| US-4355039-A | Antiinflammatory-4,5-diaryl-2-substituted-thio-imidazoles and their corresponding sulfoxides and sulfones | SCHERING, AKTIENGESELLSCHAFT (DE) | 1982-10-19 | — | — | US | claimed |
| EP-0005545-A2 | Imidazole derivatives, process for their preparation and pharmaceutical compositions containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1979-11-28 | — | — | EP | claimed |
| EP-0005545-B1 | IMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-09-18 | — | — | EP | disclosed |
| US-4440776-A | ANTIARTHRITIC AGENTS; ANTIALLERGENS; BRONCHODILATOR AGENTS; SKIN DORDERS | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-04-03 | — | — | US | disclosed |
| US-4355039-A | Antiinflammatory-4,5-diaryl-2-substituted-thio-imidazoles and their corresponding sulfoxides and sulfones | SCHERING, AKTIENGESELLSCHAFT (DE) | 1982-10-19 | — | — | US | disclosed |
| US-4269847-A | ANTIALLERGENS; DERIVATIVES OF 4,5-BIS/PHENYL-2-MERCAPTO-, THIO-, S | SCHERING AKTIENGESELLSCHAFT (DE) | 1981-05-26 | — | — | US | disclosed |
| EP-0005545-A2 | Imidazole derivatives, process for their preparation and pharmaceutical compositions containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1979-11-28 | — | — | EP | disclosed |