Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 5/20 | 0.56 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.56 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.52 |
| ▸ | AXL | P30530 | 1/20 | 0.52 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10966927 | 0.88 | CDK5 (0.64) | CDK5CDK5R1MEN1KMT2A | |
| SCHEMBL11078693 | 0.84 | MKNK1 (0.56) | MKNK1MKNK2KMT2A | |
| SCHEMBL10965295 | 0.84 | MEN1 (0.52) | CDK5CDK5R1RAB9ANPC1MEN1 | |
| SCHEMBL10965672 | 0.83 | CDK5 (0.54) | CDK5CDK5R1CYP19A1RAB9AMAPT | |
| SCHEMBL10964379 | 0.83 | CDK5 (0.54) | CDK5CDK5R1RAB9ANPC1MEN1 | |
| SCHEMBL10966867 | 0.82 | CDK5 (0.52) | CDK5CDK5R1RAB9ANPC1MEN1 | |
| SCHEMBL10966720 | 0.82 | MEN1 (0.50) | CDK5CDK5R1RAB9ANPC1MEN1 | |
| SCHEMBL10965808 | 0.81 | MEN1 (0.47) | CDK5CDK5R1CYP19A1RAB9AMAPT | |
| SCHEMBL10965193 | 0.81 | HTR2B (0.50) | CDK5CDK5R1CYP19A1RAB9ANPC1 | |
| SCHEMBL10963815 | 0.81 | MAPT (0.51) | CDK5CDK5R1RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154190-A1 | Pyridones | MERCK PATENT GmbH (DE) | 1985-09-11 | — | — | EP | disclosed |