Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 10/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 10/20 | 0.56 |
| ▸ | BTK | Q06187 | 1/20 | 0.52 |
| ▸ | CCNC | P24863 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11236769 | 0.88 | KDM4E (0.50) | MKNK1MKNK2CCNCCDK8PDE3B | |
| SCHEMBL11229059 | 0.86 | MKNK1 (0.43) | MKNK1MKNK2BTKCCNCCDK8 | |
| SCHEMBL10704473 | 0.85 | CCNC (0.67) | BTKCCNCCDK8PDE3BPDE3A | |
| SCHEMBL10965335 | 0.84 | CDK5 (0.56) | MKNK1MKNK2KMT2A | |
| SCHEMBL11315754 | 0.84 | PDE3B (0.62) | CCNCCDK8PDE3BPDE3AAURKB | |
| SCHEMBL11231128 | 0.83 | MKNK1 (0.49) | MKNK1MKNK2BTKPKN1PKN2 | |
| SCHEMBL11229727 | 0.82 | PDE3B (0.68) | MKNK1MKNK2BTKPDE3BPDE3A | |
| SCHEMBL11229029 | 0.82 | ALK (0.43) | MKNK1MKNK2PKN2PDE3BPDE3A | |
| SCHEMBL10993067 | 0.80 | PARP1 (0.46) | BTKCCNCCDK8PDE3BPDE3A | |
| SCHEMBL11233117 | 0.79 | ALDH1A1 (0.47) | LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4469871-A | Process for preparing 2-(lower-alkoxy)-1-(pyridinyl) ethenyl lower-alkyl ketones | STERLING DRUG INC. (US) | 1984-09-04 | — | — | US | disclosed |
| EP-0095152-A1 | A process for preparing nicotinonitriles and intermediates used therein | STERLING DRUG INC. (US) | 1983-11-30 | — | — | EP | disclosed |
| US-4417054-A | 2-(Lower-alkoxy)-1-(pyridinyl)ethenyl lower-alkyl ketones | STERLING DRUG INC. (US) | 1983-11-22 | — | — | US | disclosed |
| US-4365065-A | 1-(Pyridinyl)-2-(dimethylamino)ethenyl lower-alkyl ketones | STERLING DRUG INC. (US) | 1982-12-21 | — | — | US | disclosed |
| US-4313951-A | 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor | STERLING DRUG INC. (US) | 1982-02-02 | — | — | US | disclosed |