SCHEMBL10965397

SCHEMBL10965397

COC(=O)Nc1nc(-c2ccc([N+](=O)[O-])cc2)cs1

nearest known ligand 0.77

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.77
MAPT P10636 8/20 0.74
LMNA P02545 5/20 0.72
NPC1 O15118 2/20 0.67
GFER P55789 1/20 0.64
MEN1 O00255 4/20 0.63
KMT2A Q03164 4/20 0.63
GAA P10253 2/20 0.62
TDP1 Q9NUW8 1/20 0.62
POLB P06746 2/20 0.61
ROCK1 Q13464 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.56
RECQL P46063 1/20 0.55
SGK1 O00141 1/20 0.54
SIRT5 Q9NXA8 1/20 0.54
ALDH1A1 P00352 1/20 0.54
MAOA P21397 1/20 0.54
MAOB P27338 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10963704 0.88 RAB9A (0.70) RAB9AMAPTLMNANPC1GFER
SCHEMBL9621679 0.87 RAB9A (1.00) RAB9AMAPTLMNANPC1GFER
SCHEMBL10922446 0.87 RAB9A (0.80) RAB9AMAPTLMNANPC1GFER
SCHEMBL10812081 0.87 RAB9A (0.80) RAB9AMAPTLMNANPC1GFER
SCHEMBL10965903 0.85 RAB9A (0.78) RAB9AMAPTLMNANPC1GFER
SCHEMBL22500422 0.84 MAPT (0.77) RAB9AMAPTLMNANPC1GFER
SCHEMBL10966051 0.83 RAB9A (0.64) RAB9AMAPTLMNANPC1GFER
SCHEMBL11481099 0.83 RAB9A (0.74) RAB9AMAPTLMNANPC1GFER
SCHEMBL10962710 0.83 RAB9A (0.63) RAB9AMAPTLMNANPC1GFER
SCHEMBL10920855 0.82 RAB9A (0.73) RAB9AMAPTLMNANPC1GFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0068033-B1 N-(4-PHENYL-2-THIAZOLYL)CARBAMATE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICINAL COMPOSITION CONTAINING SAME MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) 1985-07-10 EP disclosed
US-4511574-A IMMUNOMODULATORS MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) 1985-04-16 US disclosed
EP-0068033-A1 N-(4-PHENYL-2-THIAZOLYL)CARBAMATE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICINAL COMPOSITION CONTAINING SAME MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) 1983-01-05 EP disclosed