Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CCR3 | P51677 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15190527 | 0.91 | CCR3 (0.63) | OPRL1POLBOPRM1CYP3A4HSD17B10 | |
| SCHEMBL698466 | 0.86 | ALDH1A1 (0.54) | OPRL1POLBOPRM1CYP3A4SIGMAR1 | |
| SCHEMBL15190515 | 0.84 | OPRL1 (0.47) | OPRL1POLBOPRM1CYP3A4HSD17B10 | |
| SCHEMBL701015 | 0.83 | OPRL1 (0.59) | OPRL1POLBOPRM1SIGMAR1KMT2A | |
| SCHEMBL13166827 | 0.81 | CYP3A4 (0.59) | OPRL1POLBOPRM1CYP3A4HSD17B10 | |
| SCHEMBL15430945 | 0.79 | CYP3A4 (0.56) | OPRL1POLBOPRM1CYP3A4HSD17B10 | |
| SCHEMBL18761020 | 0.79 | OPRL1 (0.61) | OPRL1POLBOPRM1CYP3A4HSD17B10 | |
| SCHEMBL31737430 | 0.79 | OPRL1 (0.44) | OPRL1POLBOPRM1CYP3A4HSD17B10 | |
| SCHEMBL8220836 | 0.78 | OPRL1 (0.56) | OPRL1POLBOPRM1CYP3A4HSD17B10 | |
| SCHEMBL31737166 | 0.78 | KCNJ1 (0.44) | OPRL1POLBOPRM1CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0070053-B1 | NOVEL BICYCLIC PYRIMIDIN-5-ONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-04-16 | — | — | EP | disclosed |