Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.40 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.40 |
| ▸ | NEK10 | Q6ZWH5 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | ILK | Q13418 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1572476 | 0.87 | MAPT (0.52) | MAPTKDM4EALDH1A1HSD17B10TP53 | |
| SCHEMBL7468491 | 0.75 | MAPT (0.46) | MAPTKDM4EALDH1A1HSD17B10TP53 | |
| SCHEMBL260433 | 0.74 | MAPT (0.52) | MAPTKDM4EALDH1A1HSD17B10TP53 | |
| SCHEMBL10436279 | 0.74 | TP53 (0.50) | MAPTKDM4EALDH1A1HSD17B10TP53 | |
| SCHEMBL28511808 | 0.73 | TP53 (0.37) | MAPTKDM4EALDH1A1HSD17B10TP53 | |
| SCHEMBL24897837 | 0.73 | TP53 (0.52) | MAPTKDM4EALDH1A1HSD17B10TP53 | |
| SCHEMBL591887 | 0.73 | MAPT (0.49) | MAPTKDM4EALDH1A1HSD17B10TP53 | |
| SCHEMBL3995672 | 0.73 | MAPT (0.57) | MAPTKDM4EALDH1A1HSD17B10TP53 | |
| Hydrochloric Acid SCHEMBL9036432 | 0.73 | MAPT (0.51) | MAPTKDM4EALDH1A1HSD17B10TP53 | |
| SCHEMBL5515080 | 0.71 | TP53 (0.48) | MAPTKDM4EALDH1A1HSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0077603-B1 | PROCESS AND INTERMEDIATES FOR PRODUCTION OF BENZOTHIAZINE CARBOXAMIDES | PFIZER INC. (US) | 1986-01-02 | — | — | EP | disclosed |
| US-4536573-A | REACTING BENZOTHIAZINE ESTER WITH HETEROCYCLE AMINE | PFIZER INC. (US) | 1985-08-20 | — | — | US | disclosed |
| US-4469866-A | ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1984-09-04 | — | — | US | disclosed |
| EP-0077603-A1 | Process and intermediates for production of benzothiazine carboxamides | PFIZER INC. (US) | 1983-04-27 | — | — | EP | disclosed |