Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.47 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10963663 | 0.99 | DRD2 (0.48) | DRD2MEN1CHRM2HTR1AADRA2A | |
| SCHEMBL10962499 | 0.93 | DRD3 (0.56) | DRD2MEN1CHRM2HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL10997890 | 0.93 | DRD3 (0.55) | DRD2MEN1CHRM2HTR1AADRA2A | |
| SCHEMBL11001353 | 0.89 | DRD2 (0.56) | DRD2MEN1CHRM2HTR1AADRA2A | |
| SCHEMBL10964017 | 0.89 | DRD2 (0.54) | DRD2MEN1CHRM2HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL10962413 | 0.88 | DRD2 (0.55) | DRD2MEN1CHRM2HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL10963435 | 0.88 | DRD2 (0.53) | DRD2MEN1CHRM2HTR1AADRA2A | |
| SCHEMBL10962088 | 0.83 | DRD2 (0.49) | DRD2MEN1CHRM2HTR1AADRA2A | |
| SCHEMBL10963882 | 0.82 | CHRM2 (0.52) | DRD2MEN1CHRM2HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL10963039 | 0.82 | DRD2 (0.49) | DRD2MEN1CHRM2HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4518713-A | Analgesic substituted-1-aminoalkylamino-4-aryloxypiperidines | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-05-21 | — | — | US | claimed |
| EP-0158283-A2 | Substituted 1-aminoalkylamino-4-aryloxypiperidines, a process for their preparation, intermediates thereof, and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-10-16 | — | — | EP | disclosed |