⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10967328 | 1.00 | — | — | |
| SCHEMBL14612460 | 0.81 | — | — | |
| SCHEMBL22295552 | 0.81 | — | — | |
| SCHEMBL20343563 | 0.77 | — | — | |
| SCHEMBL3060455 | 0.75 | ADH1B (0.46) | — | |
| SCHEMBL905748 | 0.75 | ADH1B (0.46) | — | |
| SCHEMBL20713597 | 0.73 | — | — | |
| SCHEMBL170579 | 0.73 | EPHX1 (0.48) | — | |
| SCHEMBL170578 | 0.73 | EPHX1 (0.48) | — | |
| SCHEMBL15182725 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119912463-A | Disubstituted amide porphyrin derivatives, preparation method thereof and use thereof as photosensitizer | 上海光声制药有限公司 | 2025-05-02 | — | — | CN | disclosed |
| US-20240294924-A1 | ANTISENSE-OLIGONUCLEOTIDES FOR PREVENTION OF KIDNEY DYSFUNCTION PROMOTED BY ENDOTHELIAL DYSFUNCTION BY EPHRIN-B2 SUPPRESSION | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2024-09-05 | — | — | US | disclosed |
| EP-4330397-A1 | ANTISENSE-OLIGONUCLEOTIDES FOR PREVENTION OF KIDNEY DYSFUNCTION PROMOTED BY ENDOTHELIAL DYSFUNCTION BY EPHRIN-B2 SUPPRESSION | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2024-03-06 | — | — | EP | disclosed |
| WO-2022263569-A1 | ANTISENSE-OLIGONUCLEOTIDES FOR PREVENTION OF KIDNEY DYSFUNCTION PROMOTED BY ENDOTHELIAL DYSFUNCTION BY EPHRIN-B2 SUPPRESSION | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2022-12-22 | — | — | WO | disclosed |
| EP-4105328-A1 | ANTISENSE-OLIGONUCLEOTIDES FOR PREVENTION OF KIDNEY DYSFUNCTION PROMOTED BY ENDOTHELIAL DYSFUNCTION BY EPHRIN-B2 SUPPRESSION | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2022-12-21 | — | — | EP | disclosed |
| US-20220143071-A1 | ANTISENSE-OLIGONUCLEOTIDES AS INHIBITORS OF TGF-R SIGNALING | Neurovision Pharma GmbH (DE) | 2022-05-12 | — | — | US | disclosed |
| US-11213541-B2 | Antisense-oligonucleotides as inhibitors of TGF-R signaling | Neurovision Pharma GmbH (DE) | 2022-01-04 | — | — | US | disclosed |
| US-20190314401-A1 | ANTISENSE-OLIGONUCLEOTIDES AS INHIBITORS OF TGF-R SIGNALING | Neurovision Pharma GmbH (DE) | 2019-10-17 | — | — | US | disclosed |
| US-10363266-B2 | Antisense-oligonucleotides as inhibitors of TGF-R signaling | Neurovision Pharma GmbH (DE) | 2019-07-30 | — | — | US | disclosed |
| US-10294261-B2 | Compound, nucleic acid, labeling substance, and detection method | KABUSHIKI KAISHA DNAFORM (JP) | 2019-05-21 | — | — | US | disclosed |
| EP-3218488-A1 | ANTISENSE-OLIGONUCLEOTIDES AS INHIBITORS OF TGF-R SIGNALING | Neurovision Pharma GmbH (DE) | 2017-09-20 | — | — | EP | disclosed |
| WO-2016075339-A1 | ANTISENSE-OLIGONUCLEOTIDES AS INHIBITORS OF TGF-R SIGNALING | Neurovision Pharma GmbH (DE) | 2016-05-19 | — | — | WO | disclosed |
| US-20160138029-A1 | ANTISENSE-OLIGONUCLEOTIDES AS INHIBITORS OF TGF-R SIGNALING | Neurovision Pharma GmbH (DE) | 2016-05-19 | — | — | US | disclosed |
| EP-3020813-A1 | Antisense-oligonucleotides as inhibitors of TGF-R signaling | Neurovision Pharma GmbH (DE) | 2016-05-18 | — | — | EP | disclosed |
| US-20150252070-A1 | COMPOUND, NUCLEIC ACID, LABELING SUBSTANCE, AND DETECTION METHOD | KABUSHIKI KAISHA DNAFORM (JP) | 2015-09-10 | — | — | US | disclosed |
| EP-2894158-A1 | COMPOUND, NUCLEIC ACID, LABELING SUBSTANCE, AND DETECTION METHOD | Kabushiki Kaisha DNAFORM (JP) | 2015-07-15 | — | — | EP | disclosed |
| US-4496727-A | ORGANIC PIGMENTS; PLASTICS; LACQUERS; INKS; COATINGS; COLOR FASTNESS | CIBA-GEIGY CORPORATION (US) | 1985-01-29 | — | — | US | disclosed |
| EP-0036388-B1 | ISOINDOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE | CIBA-GEIGY AG (CH) | 1984-02-15 | — | — | EP | disclosed |
| US-4385174-A | FOR PIGMENTS | CIBA-GEIGY CORPORATION (US) | 1983-05-24 | — | — | US | disclosed |
| EP-0036388-A2 | Isoindoline derivatives, process for their preparation and their use | CIBA-GEIGY AG (CH) | 1981-09-23 | — | — | EP | disclosed |