ADH1B

All-trans-retinol dehydrogenase [NAD(+)] ADH1B · P00325 · ADH1B on Sugi Atlas →

18,545 patent compounds predicted against ADH1B, 10,321 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL245391 SCHEMBL245391 1.00 5/20
SCHEMBL645299 SCHEMBL645299 1.00 5/20
SCHEMBL302803 SCHEMBL302803 0.61 5/20
SCHEMBL39255 SCHEMBL39255 0.50 5/20
SCHEMBL278039 SCHEMBL278039 0.43 5/20
SCHEMBL59918 SCHEMBL59918 0.41 5/20
SCHEMBL329469 SCHEMBL329469 0.41 5/20
SCHEMBL493755 SCHEMBL493755 0.41 5/20
SCHEMBL76963 SCHEMBL76963 1.00 4/20
SCHEMBL79600 SCHEMBL79600 1.00 4/20
SCHEMBL145544 SCHEMBL145544 1.00 4/20
Heptylformamide Heptylformamide (SCHEMBL146004) 1.00 4/20
SCHEMBL148472 SCHEMBL148472 1.00 4/20
SCHEMBL149028 SCHEMBL149028 1.00 4/20
SCHEMBL163669 SCHEMBL163669 1.00 4/20
SCHEMBL277123 SCHEMBL277123 1.00 4/20
SCHEMBL277517 SCHEMBL277517 1.00 4/20
SCHEMBL302735 SCHEMBL302735 1.00 4/20
SCHEMBL302790 SCHEMBL302790 1.00 4/20
SCHEMBL303563 SCHEMBL303563 1.00 4/20

Clinical trials — most relevant to ADH1B by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Efficacy and Safety of Oral Nicotinamide as an Adjunctive Therapy in Patients With Sepsis PHASE4NOT_YET_RECRUITING
Pharmacogenetics of Nicotine Addiction Treatment PHASE3COMPLETED
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome PHASE1/PHASE2COMPLETED
Sirtuin-NAD Activator in Alzheimer's Disease PHASE1/PHASE2ACTIVE_NOT_RECRUITING
Folate Rechallenge PHASE2COMPLETED
Effects of Vitamin B3 in Patients With Ataxia Telangiectasia PHASE2COMPLETED
Phase I, Dose-Escalation Study of Dihydromyricetin (DHM) to Treat Alcohol-Associated Liver Disease PHASE1NOT_YET_RECRUITING
ALDH2 Genetic Testing in East Asian Community nanNOT_YET_RECRUITING
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside nanUNKNOWN
ADH1B and ALDH Gene Variants and Lung Cancer Risk nanNOT_YET_RECRUITING
Environmental and Biological Monitoring Pilot Study for Polycyclic Aromatic Hydrocarbons in Linxian, China nanCOMPLETED
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression nanCOMPLETED
The Safety and Efficacy Study of RiaGev in Healthy Adults nanUNKNOWN
Nutritional Assessment in Patient of Mucopolysaccharide nanNOT_YET_RECRUITING
Environmental & Genetic Influences on Vitamin D Status nanCOMPLETED
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages nanCOMPLETED
Nicotinamide Riboside, Vit B3 Analogue, and Brain Energy Metabolism nanRECRUITING
Development of an Optimal Micronutrient Reference Range for Adults nanCOMPLETED
Adrenoleukodystrophy National Registry Study nanRECRUITING
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population nanUNKNOWN
EndoNAFLD: Relationship Between Fatty Liver Disease and Cardiovascular Diseases nanCOMPLETED
Role of Vitamin C Infusion in Postoperative Mechanically Ventilated Neonates With Sepsis nanCOMPLETED
Optimized Remission in Alcohol-related Liver Cirrhosis nanRECRUITING
Genetic Polymorphisms in UGT1A6 and UGT2B7 in Asian Population: Association With Lung Cancer Phenotype nanUNKNOWN
Metabolic Availability of Lysine From Barley in Young Adult Men nanNOT_YET_RECRUITING
NR Supplementation and Exercise nanCOMPLETED
Bipolar Disorder With Alcoholism in Han Chinese nanUNKNOWN
ALDH2 Single Nucleotide Polymorphisms and Prognosis of Esophageal Cancer Patients nanRECRUITING
High/Low Dose Vit A in Diarrhea/ALRI in Severe PEM nanCOMPLETED
Nicotinamide Riboside in Ulcerative Colitis nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a ADH1B binder may also engage these)

ProteinNameSimilarity
ADH1C Alcohol dehydrogenase 1C 1.000 landscape →
Q5R1W2 1.000 Q5R1W2 →
P00328 1.000 P00328 →
P14139 1.000 P14139 →
O97959 1.000 O97959 →
P80338 1.000 P80338 →
ADH1A Alcohol dehydrogenase 1A 1.000 landscape →
P19631 1.000 P19631 →
Q64415 1.000 Q64415 →
P86885 1.000 P86885 →
O19053 1.000 O19053 →
P00329 1.000 P00329 →
P23991 1.000 P23991 →
P49645 0.999 P49645 →
Q3ZC42 0.999 Q3ZC42 →
Q5RBP7 0.999 Q5RBP7 →
P00327 0.999 P00327 →
P19854 0.998 P19854 →
Q03505 0.998 Q03505 →
P28469 0.998 P28469 →
P28474 0.998 P28474 →
P80512 0.997 P80512 →
P80222 0.997 P80222 →
P79896 0.997 P79896 →
P81601 0.996 P81601 →
P41680 0.996 P41680 →
P93629 0.996 P93629 →
ADH5 Alcohol dehydrogenase class-3 0.995 landscape →
P22797 0.995 P22797 →
P86884 0.995 P86884 →