Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.56 |
| ▸ | FYN | P06241 | 6/20 | 0.49 |
| ▸ | SRC | P12931 | 6/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | VCP | P55072 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11099669 | 0.90 | EGFR (0.56) | EGFRABCG2ERBB2MAP4K4 | |
| SCHEMBL10970610 | 0.87 | FYN (0.48) | EGFRFYNSRCVCPERBB2 | |
| SCHEMBL10966607 | 0.87 | EGFR (0.48) | EGFRFYNSRCVCPERBB2 | |
| SCHEMBL10967809 | 0.87 | FYN (0.60) | EGFRFYNSRCVCPERBB2 | |
| SCHEMBL10969619 | 0.86 | FYN (0.53) | EGFRFYNSRCERBB2 | |
| SCHEMBL10967974 | 0.85 | FYN (0.47) | EGFRFYNSRCVCPERBB2 | |
| SCHEMBL10971936 | 0.85 | FYN (0.46) | EGFRFYNSRCVCPERBB2 | |
| SCHEMBL10970261 | 0.85 | FYN (0.52) | EGFRFYNSRCVCPERBB2 | |
| SCHEMBL10967392 | 0.84 | FYN (0.52) | EGFRFYNSRCVCPERBB2 | |
| SCHEMBL10967279 | 0.84 | EGFR (0.46) | EGFRFYNSRCVCPERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4543356-A | Quinazoline derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-09-24 | — | — | US | disclosed |
| EP-0030156-B1 | QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-03-21 | — | — | EP | disclosed |
| US-4429126-A | ANTIASTHMA | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-01-31 | — | — | US | disclosed |
| US-4377580-A | ANTIALLERGENIC AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-03-22 | — | — | US | disclosed |
| EP-0030156-A1 | Quinazoline derivatives, processes for their preparation and pharmaceutical compositions containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-06-10 | — | — | EP | disclosed |