Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 5/20 | 0.60 |
| ▸ | EGFR | P00533 | 10/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 5/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | GMPS | P49915 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | VCP | P55072 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10969619 | 0.92 | FYN (0.53) | FYNEGFRSRCGMPSERBB2 | |
| SCHEMBL10967974 | 0.89 | FYN (0.47) | FYNEGFRSRCERBB2VCP | |
| SCHEMBL10969943 | 0.88 | HDAC3 (0.52) | FYNEGFRKDRSRCGMPS | |
| SCHEMBL10967392 | 0.88 | FYN (0.52) | FYNEGFRKDRSRCGMPS | |
| SCHEMBL10967478 | 0.87 | EGFR (0.56) | FYNEGFRMAP4K4SRCERBB2 | |
| SCHEMBL10967279 | 0.86 | EGFR (0.46) | FYNEGFRSRCERBB2VCP | |
| SCHEMBL10970105 | 0.86 | SRC (0.57) | FYNEGFRSRCERBB2VCP | |
| SCHEMBL10970610 | 0.84 | FYN (0.48) | FYNEGFRSRCERBB2VCP | |
| SCHEMBL10966607 | 0.84 | EGFR (0.48) | FYNEGFRMAP4K4SRCERBB2 | |
| SCHEMBL10967108 | 0.83 | EGFR (0.45) | FYNEGFRSRCERBB2VCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4543356-A | Quinazoline derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-09-24 | — | — | US | disclosed |
| EP-0030156-B1 | QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-03-21 | — | — | EP | disclosed |
| US-4429126-A | ANTIASTHMA | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-01-31 | — | — | US | disclosed |
| US-4377580-A | ANTIALLERGENIC AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-03-22 | — | — | US | disclosed |
| EP-0030156-A1 | Quinazoline derivatives, processes for their preparation and pharmaceutical compositions containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-06-10 | — | — | EP | disclosed |