Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10972683 | 0.87 | NPSR1 (0.47) | NPSR1TSHRLMNABCHEALOX15 | |
| SCHEMBL4969017 | 0.80 | NPSR1 (0.76) | NPSR1TSHRLMNAALOX15ALDH1A1 | |
| SCHEMBL7562796 | 0.78 | NPSR1 (1.00) | NPSR1TSHRLMNAALOX15ALDH1A1 | |
| SCHEMBL19586294 | 0.77 | NPSR1 (0.71) | NPSR1TSHRLMNABCHEALOX15 | |
| SCHEMBL30808619 | 0.76 | NPSR1 (0.67) | NPSR1TSHRLMNAALOX15ALDH1A1 | |
| SCHEMBL4971618 | 0.76 | NPSR1 (0.67) | NPSR1TSHRLMNAALOX15ALDH1A1 | |
| SCHEMBL12301766 | 0.75 | NPSR1 (0.69) | NPSR1TSHRLMNAALOX15ALDH1A1 | |
| SCHEMBL14365495 | 0.73 | NPSR1 (0.62) | NPSR1TSHRLMNAALOX15ALDH1A1 | |
| SCHEMBL30808609 | 0.72 | NPSR1 (0.61) | NPSR1TSHRLMNAALOX15ALDH1A1 | |
| SCHEMBL7280026 | 0.70 | NPSR1 (0.62) | NPSR1TSHRLMNAALOX15ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0162776-A2 | Heterocyclic derivatives, process for their preparation and medicaments useful as aldose reductase inhibitors containing them | LABORATOIRES UPSA (FR) | 1985-11-27 | — | — | EP | disclosed |