Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 19/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 11/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 7/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5733480 | 0.86 | PTGER4 (0.48) | PTGER4PTGER3PTGER2KCNH2PTGER1 | |
| SCHEMBL5733485 | 0.86 | PTGER4 (0.48) | PTGER4PTGER3PTGER2KCNH2PTGER1 | |
| SCHEMBL11831184 | 0.84 | PTGER4 (0.53) | PTGER4PTGER3PTGER2KCNH2 | |
| SCHEMBL4995634 | 0.84 | PTGER4 (0.49) | PTGER4PTGER3PTGER2KCNH2PTGER1 | |
| SCHEMBL4995626 | 0.84 | PTGER4 (0.49) | PTGER4PTGER3PTGER2KCNH2PTGER1 | |
| SCHEMBL11159884 | 0.83 | PTGER4 (0.37) | PTGER4PTGER3PTGER2 | |
| SCHEMBL11829823 | 0.81 | PTGER4 (0.55) | PTGER4PTGER3PTGER2KCNH2 | |
| SCHEMBL11829973 | 0.81 | PTGER4 (0.75) | PTGER4PTGER3PTGER2 | |
| SCHEMBL11829979 | 0.81 | PTGER4 (0.75) | PTGER4PTGER3PTGER2 | |
| SCHEMBL11829818 | 0.81 | PTGER4 (0.55) | PTGER4PTGER3PTGER2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0046082-B1 | 8-AZA-16,16-DIFLUOROPROSTANOIDS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-06-05 | — | — | EP | claimed |
| EP-0046082-A2 | 8-Aza-16,16-difluoroprostanoids | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-02-17 | — | — | EP | claimed |
| EP-0046082-B1 | 8-AZA-16,16-DIFLUOROPROSTANOIDS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-06-05 | — | — | EP | disclosed |
| US-4320136-A | ANTIASTHMATIC, ANTIULCER PROSTAGLANDINS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-03-16 | — | — | US | disclosed |
| EP-0046082-A2 | 8-Aza-16,16-difluoroprostanoids | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-02-17 | — | — | EP | disclosed |
| US-3975399-A | PROSTAGLANDIN LIKE ACTIVITY | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1976-08-17 | — | — | US | disclosed |