SCHEMBL5733485

SCHEMBL5733485

COC(=O)CCCCCCN1C(=O)CCC1C=O

nearest known ligand 0.48

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 19/20 0.48
PTGER3 P43115 10/20 0.48
PTGER2 P43116 6/20 0.48
KCNH2 Q12809 1/20 0.43
PTGER1 P34995 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5733480 1.00 PTGER4 (0.48) PTGER4PTGER3PTGER2KCNH2PTGER1
SCHEMBL4374901 0.92 PTGER4 (0.46) PTGER4PTGER3PTGER2KCNH2
SCHEMBL4374904 0.92 PTGER4 (0.46) PTGER4PTGER3PTGER2KCNH2
SCHEMBL4995626 0.87 PTGER4 (0.49) PTGER4PTGER3PTGER2KCNH2PTGER1
SCHEMBL4995634 0.87 PTGER4 (0.49) PTGER4PTGER3PTGER2KCNH2PTGER1
SCHEMBL10969201 0.86 PTGER4 (0.47) PTGER4PTGER3PTGER2KCNH2PTGER1
SCHEMBL5215463 0.85 PTGER4 (0.52) PTGER4PTGER3PTGER2
SCHEMBL1039126 0.84 PTGER4 (0.51) PTGER4PTGER3PTGER2KCNH2
SCHEMBL1039124 0.84 PTGER4 (0.51) PTGER4PTGER3PTGER2KCNH2
SCHEMBL19513774 0.83 KAT2B (0.42) PTGER4PTGER3PTGER2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10729810-B2 Methods, systems, and compositions for promoting bone growth CAYMAN CHEMICAL COMPANY, INC (US) 2020-08-04 US disclosed
EP-3235817-B1 LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS CAYMAN CHEMICAL CO INC (US) 2018-12-12 EP disclosed
EP-3235817-A1 LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS Cayman Chemical Company, Incorporated (US) 2017-10-25 EP disclosed
EP-3235817-A1 LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS Cayman Chemical Company, Incorporated (US) 2017-10-25 EP disclosed
US-9688627-B2 Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions CAYMAN CHEMICAL COMPANY, INC. (US) 2017-06-27 US disclosed
US-9676712-B2 Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions CAYMAN CHEMICAL COMPANY, INC. (US) 2017-06-13 US disclosed
EP-2989098-B1 LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS CAYMAN CHEMICAL CO INC (US) 2017-05-10 EP disclosed
EP-2989098-B1 LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS CAYMAN CHEMICAL CO INC (US) 2017-05-10 EP disclosed
US-20160158413-A1 METHODS, SYSTEMS, AND COMPOSITIONS FOR PROMOTING BONE GROWTH CAYMAN CHEMICAL COMPANY, INC. (US) 2016-06-09 US disclosed
US-20160060216-A1 LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS CAYMAN CHEMICAL COMPANY, INCORPORATED 2016-03-03 US disclosed
US-20160031811-A1 LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS CAYMAN CHEMICAL COMPANY, INCORPORATED 2016-02-04 US disclosed
EP-1409455-B1 PROSTAGLANDIN ANALOGUES-AS EP4 RECEPTOR AGONISTS HOFFMANN LA ROCHE (CH) 2006-01-04 EP disclosed
US-6900336-B2 8-aza-11-deoxy prostaglandin analogues SYNTEX (U.S.A.) LLC (US) 2005-05-31 US disclosed
EP-1409455-A1 PROSTAGLANDIN ANALOGUES-AS EP4 RECEPTOR AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2004-04-21 EP disclosed
US-20030120079-A1 Such as 7-((R)-2-((E)-3-(3-Benzyl-phenyl)-3-hydroxy-propenyl)-5-oxo-pyrrolidin-1-yl)-heptanoic acid; side effects reduction SYNTEX (U.S.A.) LLC 2003-06-26 US disclosed
WO-2003008377-A1 PROSTAGLANDIN ANALOGUES_AS EP4 RECEPTOR AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2003-01-30 WO disclosed
US-4113873-A 8-AZAPROSTANOIC ACID DERIVATIVES TANABE SEIYAKU CO. LTD. (JP) 1978-09-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160031811-A1 LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS PTGER4, PTGER1, PTGER3 PTGER4 1/4885PTGER3 3/4885PTGER2 4/4885
US-20030120079-A1 Such as 7-((R)-2-((E)-3-(3-Benzyl-phenyl)-3-hydroxy-propenyl)-5-oxo-pyrrolidin-1-yl)-heptanoic acid; side effects reduction PTGER4, FFAR4, PTGER1 PTGER4 1/4885PTGER3 11/4885PTGER2 15/4885
US-20160060216-A1 LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS PTGER4, PTGER1, PTGER3 PTGER4 1/4885PTGER3 3/4885PTGER2 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.