Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CD38 | P28907 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | QPCT | Q16769 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11878058 | 0.98 | CD38 (0.46) | HTTCD38GAAQPCTEPHX1 | |
| SCHEMBL1425379 | 0.95 | CD38 (0.43) | HTTCD38GAAQPCTEPHX1 | |
| SCHEMBL24908113 | 0.94 | CD38 (0.43) | HTTCD38GAAQPCTEPHX1 | |
| SCHEMBL1934143 | 0.91 | CD38 (0.39) | HTTCD38GAAQPCTMAPT | |
| SCHEMBL12018143 | 0.85 | EPHX2 (0.44) | CD38MAPTEPHX2CYP2C19 | |
| SCHEMBL23435085 | 0.83 | CD38 (0.52) | CD38EPHX2 | |
| SCHEMBL18073599 | 0.80 | EPHX2 (0.39) | CD38NPC1RAB9AMAPTEPHX2 | |
| SCHEMBL4618043 | 0.80 | KMT2A (0.39) | HTTKDM4EALDH1A1EPHX2 | |
| SCHEMBL6102108 | 0.80 | KMT2A (0.39) | HTTKDM4EALDH1A1EPHX2 | |
| SCHEMBL18078095 | 0.79 | CD38 (0.37) | CD38ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0197840-A1 | (Imidazolyl-4) piperidines, their preparation and their therapeutical use | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1986-10-15 | — | — | EP | disclosed |
| US-4542139-A | HYPOGLYCEMIC AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-09-17 | — | — | US | disclosed |
| US-4379785-A | Heterocyclic substituted sulfonyl ureas, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-04-12 | — | — | US | disclosed |
| US-4379153-A | Benzenesulfonyl ureas, and pharmaceutical preparations | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-04-05 | — | — | US | disclosed |
| US-4325963-A | ANTIDIABETIC AGENT | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-04-20 | — | — | US | disclosed |
| US-4315940-A | Antidiabetic 1-piperidine-sulfonylureas | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-02-16 | — | — | US | disclosed |
| US-4282239-A | HYPOTENSIVE AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-08-04 | — | — | US | disclosed |
| US-4157395-A | TREATMENT OF DIABETES | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-06-05 | — | — | US | disclosed |
| US-4025519-A | HYPOGLYCEMIC AGENTS | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-05-24 | — | — | US | disclosed |
| US-3962244-A | LOWERING OF BLOOD-SUGAR LEVELS | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-06-08 | — | — | US | disclosed |