SCHEMBL10969657

SCHEMBL10969657

Cc1ccc(C(Cn2cncn2)Cn2cncn2)c(F)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 3/20 0.38
ALDH1A1 P00352 2/20 0.38
PKM P14618 1/20 0.38
CYP3A4 P08684 2/20 0.37
CYP2C19 P33261 2/20 0.37
LMNA P02545 1/20 0.37
HSP90AA1 P07900 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP11B1 P15538 1/20 0.37
CYP11B2 P19099 1/20 0.37
ADRA1A P35348 1/20 0.37
CYP51A1 Q16850 1/20 0.37
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
OPRM1 P35372 1/20 0.36
OPRD1 P41143 1/20 0.36
NPSR1 Q6W5P4 2/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
NPC1 O15118 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11079034 0.85 OPRM1 (0.40) CYP19A1ALDH1A1PKMCYP3A4CYP2C19
SCHEMBL3793619 0.85 CYP3A4 (0.51) CYP19A1CYP3A4CYP2C19LMNAHSP90AA1
SCHEMBL10971747 0.81 NPC1 (0.46) CYP19A1ALDH1A1PKMOPRM1OPRD1
SCHEMBL10972434 0.80 CYP19A1 (0.43) CYP19A1ALDH1A1CYP3A4CYP2C19LMNA
SCHEMBL16520840 0.80 CYP3A4 (0.37) CYP19A1ALDH1A1PKMCYP3A4CYP2C19
SCHEMBL30788056 0.78 CYP3A4 (0.50) CYP19A1CYP3A4CYP2C19LMNAHSP90AA1
SCHEMBL20365808 0.76 MC4R (0.44) CYP19A1CYP3A4CYP2C19LMNAHSP90AA1
SCHEMBL10972636 0.75 NPSR1 (0.48) CYP19A1ALDH1A1CYP3A4CYP2C19HSP90AA1
SCHEMBL9480588 0.75 OPRM1 (0.36) ALDH1A1PKMCYP3A4CYP2C19HSP90AA1
SCHEMBL24136282 0.74 CYP3A4 (0.49) CYP19A1ALDH1A1CYP3A4CYP2C19LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0148858-A1 NOVEL TRIAZOLYL-SUBSTITUTED PROPANE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SCHERING CORPORATION (US) 1985-07-24 EP disclosed
WO-1984004918-A1 NOVEL TRIAZOLYL-SUBSTITUTED PROPANE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SCHERING CORP (US) 1984-12-20 WO disclosed
EP-0127865-A1 Novel triazolyl-substituted propane derivatives, their preparation and pharmaceutical compositions containing them SCHERING CORPORATION (US) 1984-12-12 EP disclosed
US-4482564-A FUNGICIDES SCHERING CORPORATION (US) 1984-11-13 US disclosed