Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 9/20 | 0.56 |
| ▸ | RAB9A | P51151 | 8/20 | 0.56 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.56 |
| ▸ | GPR27 | Q9NS67 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | TYK2 | P29597 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10520399 | 0.84 | METAP2 (0.70) | METAP2NPC1RAB9ASMN1; SMN2MAOB | |
| SCHEMBL12468660 | 0.83 | AVPR2 (0.76) | METAP2NPC1RAB9AAVPR2GPR27 | |
| SCHEMBL4141992 | 0.81 | KMT2A (0.75) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL11582824 | 0.81 | AKR1C3 (0.62) | NPC1RAB9AAVPR2GPR27SMN1; SMN2 | |
| SCHEMBL29771489 | 0.81 | AKR1C3 (0.62) | NPC1RAB9AAVPR2GPR27SMN1; SMN2 | |
| SCHEMBL11648261 | 0.81 | NPC1 (0.68) | NPC1RAB9AAVPR2GPR27SMN1; SMN2 | |
| SCHEMBL12468557 | 0.81 | AVPR2 (0.75) | NPC1RAB9AAVPR2GPR27SMN1; SMN2 | |
| SCHEMBL30786728 | 0.81 | KMT2A (0.75) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL7865531 | 0.80 | NPC1 (0.58) | NPC1RAB9AAVPR2GPR27SMN1; SMN2 | |
| SCHEMBL29627549 | 0.80 | KMT2A (0.73) | NPC1RAB9AAVPR2GPR27SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0098934-B1 | 2-METHYLSELENO-BENZAMIDES | A. Nattermann & Cie. GmbH (DE) | 1985-12-27 | — | — | EP | disclosed |
| EP-0098934-A1 | 2-Methylseleno-benzamides | A. Nattermann & Cie. GmbH (DE) | 1984-01-25 | — | — | EP | disclosed |
| US-4418069-A | Benzisoselenazolones and process for the treatment of rheumatic and arthritic diseases using them | A. NATTERMANN & CIE GMBH (DE) | 1983-11-29 | — | — | US | disclosed |
| EP-0044453-A2 | New benzisoselenazolones, process for producing the same and pharmaceutical preparations containing the same | A. Nattermann & Cie. GmbH (DE) | 1982-01-27 | — | — | EP | disclosed |