Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10971007 | 1.00 | MAPT (0.63) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL8624953 | 0.80 | LSS (0.49) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL8624956 | 0.80 | LSS (0.49) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL27225877 | 0.80 | MAPT (0.79) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL9603179 | 0.80 | MAPT (0.79) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL8618485 | 0.79 | LSS (0.48) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL8621505 | 0.79 | LSS (0.48) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL2553009 | 0.79 | MAPT (1.00) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL770290 | 0.79 | MAPT (1.00) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL1008045 | 0.79 | MAPT (1.00) | MAPTRXFP1HDAC3MAPK1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153403-A4 | CHEMICAL COMPOUNDS. | MALLINCKRODT INC (US) | 1985-12-11 | — | — | EP | disclosed |
| EP-0153403-A1 | CHEMICAL COMPOUNDS | Mallinckrodt, Inc. (a Delaware corporation) (US) | 1985-09-04 | — | — | EP | disclosed |
| WO-1985000753-A1 | CHEMICAL COMPOUNDS | MALLINCKRODT, INC. (US) | 1985-02-28 | — | — | WO | disclosed |