Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11287381 | 1.00 | KCNH2 (0.50) | KCNH2PPARAALDH1A1PKMHPGD | |
| SCHEMBL27667694 | 1.00 | KCNH2 (0.50) | KCNH2PPARAALDH1A1PKMHPGD | |
| SCHEMBL11221564 | 1.00 | KCNH2 (0.50) | KCNH2PPARAALDH1A1PKMHPGD | |
| SCHEMBL27868271 | 1.00 | KCNH2 (0.50) | KCNH2PPARAALDH1A1PKMHPGD | |
| SCHEMBL4750615 | 1.00 | KCNH2 (0.50) | KCNH2PPARAALDH1A1PKMHPGD | |
| SCHEMBL27667746 | 1.00 | KCNH2 (0.50) | KCNH2PPARAALDH1A1PKMHPGD | |
| SCHEMBL9190698 | 1.00 | KCNH2 (0.50) | KCNH2PPARAALDH1A1PKMHPGD | |
| SCHEMBL4579897 | 1.00 | KCNH2 (0.50) | KCNH2PPARAALDH1A1PKMHPGD | |
| SCHEMBL6417360 | 1.00 | KCNH2 (0.50) | KCNH2PPARAALDH1A1PKMHPGD | |
| Hydrochloric Acid SCHEMBL29183931 | 0.98 | KCNH2 (0.48) | KCNH2PPARAALDH1A1PKMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10988477-B2 | GCN2 inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2021-04-27 | — | — | US | disclosed |
| US-20210040083-A1 | GCN2 INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2021-02-11 | — | — | US | disclosed |
| US-10793563-B2 | GCN2 inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2020-10-06 | — | — | US | disclosed |
| US-20190233411-A1 | GCN2 INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-08-01 | — | — | US | disclosed |
| CN-109844069-A | Utilize isobutane alkylation oil plant amylene | 雪佛龙美国公司 | 2019-06-04 | — | — | CN | disclosed |
| EP-0131302-A2 | Imidazolium salts, intermediates thereto and their use | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-01-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190233411-A1 | GCN2 INHIBITORS AND USES THEREOF | EIF2AK4, GCN1, GCGR | KCNH2 4052/4885PPARA 3845/4885ALDH1A1 4414/4885 |
| US-20210040083-A1 | GCN2 INHIBITORS AND USES THEREOF | EIF2AK4, GCN1, GCGR | KCNH2 4052/4885PPARA 3845/4885ALDH1A1 4414/4885 |
| US-10988477-B2 | GCN2 inhibitors and uses thereof | EIF2AK4, GCN1, EIF2AK1 | KCNH2 3897/4885PPARA 4037/4885ALDH1A1 4754/4885 |
| US-10793563-B2 | GCN2 inhibitors and uses thereof | EIF2AK4, GCN1, GCGR | KCNH2 4052/4885PPARA 3845/4885ALDH1A1 4414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.