GCN1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to GCN1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Counteracting Deleterious Metabolic Glucocorticoid Effects With Metformin	PHASE4	COMPLETED
Rapid Effects of Hydrocortisone on Glucose-induced Insulin Secretion in Healthy Humans	PHASE4	COMPLETED
Effects of Liraglutide on ER Stress in Obese Patients With Type 2 Diabetes	PHASE4	UNKNOWN
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit	PHASE2/PHASE3	WITHDRAWN
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
Targeting Endoplasmic Reticulum Stress in Human Hypertension	PHASE1/PHASE2	RECRUITING
Reverse Transcriptase Inhibitors in AGS	PHASE2	COMPLETED
Study of Decitabine in Combination With Sequential Rapamycin or Ribavirin in High Risk AML Patients	PHASE1/PHASE2	COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors	PHASE1	COMPLETED
PBA Use for Treatment of ATF6-/- Patients	EARLY_PHASE1	SUSPENDED
The Role of Glucocorticoids to Maintain Energy Homeostasis During Starvation (Gluco-Starve)	EARLY_PHASE1	COMPLETED
Quantification of GADD34 Expression in RA	nan	COMPLETED
Effect of Branched Chain Amino Acids on Muscle	nan	COMPLETED
Effects of a Multiple Sclerosis Relapse Therapy on Offspring Neurocognitive Development and Behaviour	nan	UNKNOWN
Intermittent Fasting for Pancreatitis	nan	NOT_YET_RECRUITING
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress	nan	WITHDRAWN
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Alternate Day Fasting After Surgery for Patients Undergoing Chemotherapy	nan	RECRUITING
Impacts of Mechanistic Target of Rapamycin (mTOR) Inhibition on Aged Human Muscle (Rapamune)	nan	RECRUITING
SMYD3-Driven Metabolic Rewiring in Colorectal Liver Metastases	nan	NOT_YET_RECRUITING
Establishment of Human Cellular Disease Models for Wilson Disease	nan	COMPLETED
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML)	nan	COMPLETED
Protein Intake and Step Reduction in Older Adults	nan	COMPLETED
Rapamycin as a Means of Interference With Reconsolidation of Posttraumatic Stress Disorder-related Traumatic Memory	nan	COMPLETED
Enhanced Protein Intake to Support Muscle Protein Synthesis in ICU	nan	RECRUITING
The Effects of Whey vs. Collagen on MPS	nan	COMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation	nan	COMPLETED
miR-155 Expression in Episodic and Chronic Migraine	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a GCN1 binder may also engage these)

Protein	Name	Similarity
E9PVA8	—	1.000	E9PVA8 →
E7FGT5	—	1.000	E7FGT5 →
Q5XG71	—	1.000	Q5XG71 →
Q9DEI1	—	0.999	Q9DEI1 →
Q4V9P9	—	0.999	Q4V9P9 →
Q3TQQ9	—	0.999	Q3TQQ9 →
Q5ZM41	—	0.998	Q5ZM41 →
A2AKG8	—	0.998	A2AKG8 →
Q80UK8	—	0.998	Q80UK8 →
Q5RDK1	—	0.997	Q5RDK1 →
C5J7W8	—	0.997	C5J7W8 →
E1C231	—	0.997	E1C231 →
P42173	—	0.996	P42173 →
Q3UGY8	—	0.996	Q3UGY8 →
UTP20	Small subunit processome component 20 homolog	0.996	landscape →
Q9VJ29	—	0.995	Q9VJ29 →
O14981	—	0.995	O14981 →
O60287	—	0.995	O60287 →
Q3URQ0	—	0.995	Q3URQ0 →
E7FH61	—	0.995	E7FH61 →
Q8BJW5	—	0.995	Q8BJW5 →
Q8BKX6	—	0.995	Q8BKX6 →
Q9H0H0	—	0.995	Q9H0H0 →
Q6A009	—	0.995	Q6A009 →
P97313	—	0.994	P97313 →
Q7SY48	—	0.994	Q7SY48 →
Q86XI2	—	0.994	Q86XI2 →
Q96N11	—	0.994	Q96N11 →
Q751Y8	—	0.994	Q751Y8 →
Q9V677	—	0.994	Q9V677 →