Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 3/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10933276 | 0.99 | PPARG (0.41) | GRIN1GRIN2BPPARGPPARACCR2 | |
| SCHEMBL10973444 | 0.80 | PPARG (0.45) | PPARGPPARACCR2HTR2CHTR7 | |
| Hydrochloric Acid SCHEMBL10935760 | 0.79 | PPARG (0.44) | PPARGPPARACCR2HTR2CHTR7 | |
| SCHEMBL9501543 | 0.78 | HTR7 (0.51) | GRIN1GRIN2BPPARGPPARAHTR7 | |
| SCHEMBL10975299 | 0.78 | HTR2C (0.43) | PPARGPPARACCR2HTR2CHTR7 | |
| Hydrochloric Acid SCHEMBL10939473 | 0.78 | HTR7 (0.50) | GRIN1GRIN2BPPARGPPARAHTR2C | |
| Hydrochloric Acid SCHEMBL9485518 | 0.78 | HTR7 (0.50) | GRIN1GRIN2BPPARGPPARAHTR2C | |
| Hydrochloric Acid SCHEMBL10740874 | 0.77 | HTR2C (0.44) | PPARGPPARACCR2HTR2CHTR7 | |
| SCHEMBL10975429 | 0.77 | HTR7 (0.54) | PPARGPPARAHTR7CACNA1B | |
| Hydrochloric Acid SCHEMBL10938007 | 0.76 | HTR7 (0.53) | PPARGPPARAHTR7CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0101381-B1 | ANOREXIC TRIFLUOROMETHYL PHENYL TETRAHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI S.A. (FR) | 1985-12-04 | — | — | EP | disclosed |
| EP-0101381-A1 | Anorexic trifluoromethyl phenyl tetrahydropyridines, process for their preparation and pharmaceutical compositions containing them | SANOFI S.A. (FR) | 1984-02-22 | — | — | EP | disclosed |