Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 14/20 | 0.73 |
| ▸ | EGFR | P00533 | 2/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15587571 | 0.85 | MAP4K4 (1.00) | MAP4K4 | |
| SCHEMBL14537165 | 0.83 | MAP4K4 (0.81) | MAP4K4 | |
| SCHEMBL23758885 | 0.82 | EGFR (0.53) | MAP4K4EGFRPTPN1 | |
| SCHEMBL6092610 | 0.81 | ULK1 (0.61) | MAP4K4 | |
| SCHEMBL15587548 | 0.80 | MAP4K4 (1.00) | MAP4K4 | |
| SCHEMBL10965800 | 0.79 | MAP4K4 (0.57) | MAP4K4 | |
| SCHEMBL6093993 | 0.78 | MAP4K4 (0.53) | MAP4K4 | |
| SCHEMBL15587447 | 0.78 | MAP4K4 (1.00) | MAP4K4 | |
| SCHEMBL10967231 | 0.78 | EGFR (0.61) | MAP4K4EGFRPTPN1 | |
| SCHEMBL11099106 | 0.76 | EGFR (0.59) | MAP4K4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4543356-A | Quinazoline derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-09-24 | — | — | US | disclosed |
| EP-0030156-B1 | QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-03-21 | — | — | EP | disclosed |
| US-4429126-A | ANTIASTHMA | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-01-31 | — | — | US | disclosed |
| US-4377580-A | ANTIALLERGENIC AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-03-22 | — | — | US | disclosed |
| EP-0030156-A1 | Quinazoline derivatives, processes for their preparation and pharmaceutical compositions containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-06-10 | — | — | EP | disclosed |