Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10977910 | 0.85 | PIK3CD (0.45) | PIK3CDRAB9AADRA1BADRA1AKMT2A | |
| SCHEMBL9319724 | 0.83 | GAA (0.42) | PIK3CDRAB9AKMT2AMEN1L3MBTL1 | |
| SCHEMBL628723 | 0.80 | PIK3CD (0.50) | PIK3CDRAB9AADRA1BADRA1AKMT2A | |
| SCHEMBL9812335 | 0.80 | PIK3CD (0.50) | PIK3CDRAB9AADRA1BADRA1AKMT2A | |
| SCHEMBL9319736 | 0.80 | GAA (0.42) | PIK3CDRAB9AKMT2AMEN1L3MBTL1 | |
| SCHEMBL24072918 | 0.79 | ALOX5 (0.47) | PIK3CDRAB9AADRA1BADRA1AKMT2A | |
| SCHEMBL3732638 | 0.79 | ALOX5 (0.47) | PIK3CDRAB9AADRA1BADRA1AKMT2A | |
| SCHEMBL245238 | 0.79 | ALOX5 (0.47) | PIK3CDRAB9AADRA1BADRA1AKMT2A | |
| SCHEMBL10792403 | 0.79 | ALOX5 (0.47) | PIK3CDRAB9AADRA1BADRA1AKMT2A | |
| SCHEMBL31602012 | 0.79 | ALOX5 (0.47) | PIK3CDRAB9AADRA1BADRA1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0060610-B1 | HEXAHYDRO-TRANS- AND TETRAHYDROPYRIDOINDOLE NEUROLEPTIC AGENTS | PFIZER INC. (US) | 1985-09-04 | — | — | EP | disclosed |
| US-4432978-A | NEUROLEPTIC AGENTS, TRANQUILIZERS | PFIZER INC. (US) | 1984-02-21 | — | — | US | disclosed |
| US-4431649-A | TRANQUILIZERS | PFIZER INC. (US) | 1984-02-14 | — | — | US | disclosed |
| US-4431646-A | TRANQUILIZERS; PSYCHOSIS; NERVOUS SYSTEM DISORDERS | PFIZER INC. (US) | 1984-02-14 | — | — | US | disclosed |
| US-4427679-A | TRANQUILIZERS; PSYCHOLOGICAL DISORDERS | PFIZER INC. (US) | 1984-01-24 | — | — | US | disclosed |
| EP-0060610-A1 | Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents | PFIZER INC. (US) | 1982-09-22 | — | — | EP | disclosed |
| US-4337250-A | NEUROLEPTIC AGENTS | PFIZER INC. (US) | 1982-06-29 | — | — | US | disclosed |