Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.59 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.58 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.55 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.55 |
| ▸ | RORC | P51449 | 2/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | VNN1 | O95497 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27717813 | 0.89 | HDAC1 (0.63) | HDAC3HDAC1HDAC2HDAC6MEN1 | |
| SCHEMBL1735277 | 0.88 | CSNK2A1 (0.68) | HDAC3HDAC1HDAC2HDAC6MAP4K4 | |
| SCHEMBL10971529 | 0.88 | HDAC1 (0.61) | HDAC3HDAC1HDAC2HDAC6MEN1 | |
| SCHEMBL1735203 | 0.88 | HDAC1 (0.61) | HDAC3HDAC1HDAC2HDAC6CA1 | |
| SCHEMBL10971409 | 0.86 | HDAC3 (0.59) | HDAC3HDAC1HDAC2HDAC6MEN1 | |
| SCHEMBL14499163 | 0.86 | PTK2 (0.62) | HDAC3HDAC1HDAC2HDAC6KDR | |
| SCHEMBL1734422 | 0.85 | KCNK9 (0.55) | HDAC3HDAC1HDAC2HDAC6MEN1 | |
| SCHEMBL13605541 | 0.85 | HDAC3 (0.55) | HDAC3HDAC1HDAC2HDAC6CSNK2A1 | |
| SCHEMBL8997871 | 0.83 | RORC (0.69) | MAP4K4PARP10CA1CA2PARP1 | |
| SCHEMBL13605518 | 0.83 | HDAC1 (0.58) | HDAC3HDAC1HDAC2HDAC6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0164204-A1 | Novel pharmaceutically useful pyrimidines | FISONS plc (GB) | 1985-12-11 | — | — | EP | claimed |
| EP-0164204-A1 | Novel pharmaceutically useful pyrimidines | FISONS plc (GB) | 1985-12-11 | — | — | EP | disclosed |