Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 1.00 |
| ▸ | DRD3 | P35462 | 13/20 | 1.00 |
| ▸ | DRD4 | P21917 | 6/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | HTR1A | P08908 | 2/20 | 0.67 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CASP1 | P29466 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10896624 | 0.94 | DRD2 (1.00) | DRD2DRD3DRD4HTR1A | |
| Hydrochloric Acid SCHEMBL10898263 | 0.93 | DRD2 (0.97) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL9558523 | 0.91 | DRD2 (0.83) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL7388513 | 0.89 | DRD2 (0.78) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL6334837 | 0.88 | DRD2 (0.77) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL6334843 | 0.88 | DRD2 (0.77) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL6343662 | 0.86 | DRD2 (0.74) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL9757621 | 0.86 | DRD2 (0.83) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL2699094 | 0.86 | DRD2 (0.73) | DRD2DRD3DRD4 | |
| SCHEMBL11496079 | 0.85 | DRD2 (0.82) | DRD2DRD3DRD4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055043-B1 | 6,7,8,9-TETRAHYDRO-3H-BENZ(E)INDOLAMINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND INTERMEDIATES USED THEREIN, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE INDOLAMINE DERIVATIVES | AYERST, MCKENNA AND HARRISON INC. (CA) | 1985-01-23 | — | — | EP | disclosed |
| US-4442126-A | PARKINSON*S DISEASE, CARDIOVASCULAR DISORDERS | SYNTHELABO (FR) | 1984-04-10 | — | — | US | disclosed |
| US-4370341-A | 6,7,8,9-Tetrahydro-3H-benz[E]indol-8-amine derivatives | AYERST, MCKENNA & HARRISON, LTD. (CA) | 1983-01-25 | — | — | US | disclosed |
| EP-0055043-A2 | 6,7,8,9-Tetrahydro-3H-benz(e)indolamine derivatives, processes for their preparation and intermediates used therein, and pharmaceutical compositions containing the indolamine derivatives | AYERST, MCKENNA AND HARRISON INC. (CA) | 1982-06-30 | — | — | EP | disclosed |