Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.71 |
| ▸ | TP53 | P04637 | 2/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | GAA | P10253 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.67 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25720785 | 0.78 | PDE5A (0.79) | MAPTSMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL16770015 | 0.78 | SMN1; SMN2 (0.57) | MAPTTP53SMN1; SMN2GAAMEN1 | |
| Hydrochloric Acid SCHEMBL6622281 | 0.78 | ADRB3 (0.80) | MAPTTP53SMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL6622276 | 0.78 | ADRB3 (0.80) | MAPTTP53SMN1; SMN2GAA | |
| SCHEMBL2409605 | 0.77 | MEN1 (0.57) | MAPTTP53SMN1; SMN2GAAMEN1 | |
| SCHEMBL1128988 | 0.76 | SMN1; SMN2 (0.59) | MAPTTP53SMN1; SMN2GAAMEN1 | |
| SCHEMBL26334694 | 0.76 | SMN1; SMN2 (0.56) | MAPTTP53SMN1; SMN2GAAMEN1 | |
| SCHEMBL23140029 | 0.76 | CTPS1 (0.75) | MAPTMEN1KMT2ASLC12A2SLC12A5 | |
| Hydrochloric Acid SCHEMBL826687 | 0.76 | MEN1 (0.56) | MAPTTP53SMN1; SMN2GAAMEN1 | |
| SCHEMBL5544118 | 0.76 | MAPT (0.56) | MAPTTP53SMN1; SMN2GAASLC12A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0066993-B1 | QUINOLINE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-01-30 | — | — | EP | disclosed |
| US-4435405-A | 2-(AMINOALKYLTHIO) SUBSTITUTED | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-03-06 | — | — | US | disclosed |
| EP-0066993-A1 | Quinoline derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-12-15 | — | — | EP | disclosed |