Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 3/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | GLI1 | P08151 | 1/20 | 0.37 |
| ▸ | ARG1 | P05089 | 1/20 | 0.37 |
| ▸ | SCN4A | P35499 | 1/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL27900532 | 0.92 | NOS2 (0.47) | NOS2NOS3NOS1MEN1BLM | |
| Proline SCHEMBL719217 | 0.90 | PRCP (0.46) | NOS2NOS3NOS1MEN1BLM | |
| Proline SCHEMBL719216 | 0.90 | PRCP (0.46) | NOS2NOS3NOS1MEN1BLM | |
| Proline SCHEMBL10984319 | 0.89 | PRCP (0.43) | NOS2NOS3NOS1MEN1BLM | |
| Proline SCHEMBL28130345 | 0.88 | NOS2 (0.50) | NOS2NOS3NOS1MEN1BLM | |
| Proline SCHEMBL3266119 | 0.86 | MEN1 (0.45) | NOS2NOS3NOS1MEN1BLM | |
| Proline SCHEMBL3266120 | 0.86 | MEN1 (0.45) | NOS2NOS3NOS1MEN1BLM | |
| Proline SCHEMBL28049461 | 0.86 | MEN1 (0.48) | NOS2NOS3NOS1MEN1BLM | |
| Proline SCHEMBL27694737 | 0.86 | NOS2 (0.52) | NOS2NOS3NOS1MEN1BLM | |
| Proline SCHEMBL10141185 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4533656-A | PYRROLE OR PYRIDINE CARBONYLSULFONAMIDES FOR TREATMENT OF HYPERTENSION OR CONJESTIVE HEART FAILURE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-08-06 | — | — | US | disclosed |
| EP-0099709-A2 | Amide derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-02-01 | — | — | EP | disclosed |