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Sugi Predict / Targets / NOS2

NOS2

Nitric oxide synthase, inducible · P35228 · NOS2 on Sugi Atlas →

135,525 patent compounds predicted against NOS2, 60,580 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL82945 SCHEMBL82945 0.73 11/20
SCHEMBL160399 SCHEMBL160399 0.73 10/20
Arginine Arginine (SCHEMBL43261) 1.00 9/20
Bardoxolone Bardoxolone (SCHEMBL69892) 1.00 9/20
SCHEMBL91617 SCHEMBL91617 1.00 9/20
Bardoxolone Bardoxolone (SCHEMBL92342) 1.00 9/20
SCHEMBL144428 SCHEMBL144428 1.00 9/20
SCHEMBL43288 SCHEMBL43288 0.89 9/20
SCHEMBL92364 SCHEMBL92364 0.85 9/20
Bardoxolone Methyl Bardoxolone Methyl (SCHEMBL91615) 0.83 9/20
SCHEMBL91616 SCHEMBL91616 0.83 9/20
SCHEMBL82942 SCHEMBL82942 0.77 9/20
SCHEMBL156221 SCHEMBL156221 0.72 9/20
SCHEMBL84160 SCHEMBL84160 0.63 9/20
SCHEMBL82937 SCHEMBL82937 0.63 9/20
SCHEMBL82953 SCHEMBL82953 0.62 9/20
SCHEMBL83744 SCHEMBL83744 0.62 9/20
SCHEMBL83431 SCHEMBL83431 0.60 9/20
SCHEMBL91613 SCHEMBL91613 0.60 9/20
SCHEMBL83750 SCHEMBL83750 0.60 9/20

Clinical trials — most relevant to NOS2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Sickle Cell Disease Treatment With Arginine Therapy (STArT) Trial PHASE3COMPLETED
Methylene Blue in Early Septic Shock PHASE2/PHASE3COMPLETED
Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in Sepsis PHASE3COMPLETED
Minocyclin in Ulcerative Colitis as Added on Therapy PHASE2COMPLETED
COMP-4 Supplementation and Brachial Artery FMD PHASE1/PHASE2COMPLETED
Evaluation of Two Doses of Nitric Oxide (NO) Given Intermittently Via Inhalation to Subjects With Bronchiolitis PHASE2COMPLETED
Networked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKE PHASE2UNKNOWN
The STRETCH Study: Distensibility on Endothelial-Dependent Vasoreactivity in Subjects With Systolic Hypertension PHASE2COMPLETED
Simvastatin in Secondary Progressive Multiple Sclerosis PHASE2COMPLETED
STRETCH Study: Effect of Distensibility on Endothelial-Dependent Vasoreactivity in Patients With ISH PHASE2COMPLETED
Influence of Dietary Nitrate on Skin Inflammation PHASE1COMPLETED
Effect of Simvastatin on CF Airway Inflammation PHASE1COMPLETED
Possible Effects of Propylthiouracil, Riociguat and Perphenazine on Circulation of Healthy Volunteers PHASE1COMPLETED
Impact of NOS, COX, and ROS Inhibition on Cerebral Blood Flow Regulation PHASE1WITHDRAWN
L-Citrulline and Endothelial Function PHASE1COMPLETED
iNOS With Positron Emission Tomography (PET) in Cellular Inflammation. EARLY_PHASE1COMPLETED
The Acute Effect of a Walnut Intervention on Cognitive Performance, Brain Activation, and Serum Markers of Inflammation in Young Adults nanCOMPLETED
Palmitoylethanolamide in Ulcerative Colitis nanNOT_YET_RECRUITING
Fetal Alcohol Spectrum Disorder-Is This a Ciliopathy? nanCOMPLETED
Systemic Nitrosative/Oxidative Stress in Patients with Acute Brain Injury nanUNKNOWN
OrthoCor Advanced Trial for Knee Osteoarthritis nanCOMPLETED
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD nanUNKNOWN
NO Donors and Inhibitors to Study Imbalance of Nitrogen Stress and Antioxidant Defense in COPD nanCOMPLETED
Detection and Use of Nasal Nitrous Oxide and the Electronic Nose nanCOMPLETED
Nitric Oxide (NO) Donors and Inhibitors Study: Study to Evaluate L-Arginine and Aminoguanidine in Asthmatic Subjects nanCOMPLETED
Thyme Honey Mouthwash in Management of Periodontitis in Renal Patients nanCOMPLETED
Effects of Trehalose and Polyphenols in Vasculopathic Patients nanCOMPLETED
Oxidative Stress and Endothelial Function in Pregnancy Complications nanUNKNOWN
Exercise-related Irisin on Inflammation and Pain nanUNKNOWN
Methylene Blue in Sepsis: A Randomized Controlled Trial nanWITHDRAWN

Related proteins — ESM-2 sequence neighbours (a NOS2 binder may also engage these)

ProteinNameSimilarity
Q28314 — 1.000 Q28314 →
P79290 — 1.000 P79290 →
Q06518 — 1.000 Q06518 →
O62699 — 1.000 O62699 →
Q27995 — 1.000 Q27995 →
P29477 — 1.000 P29477 →
Q26240 — 0.998 Q26240 →
Q90703 — 0.998 Q90703 →
O54705 — 0.997 O54705 →
Q8T8C0 — 0.997 Q8T8C0 →
O61309 — 0.996 O61309 →
O61608 — 0.995 O61608 →
Q92091 — 0.994 Q92091 →
B1B557 — 0.994 B1B557 →
Q9D5Z5 — 0.993 Q9D5Z5 →
Q28969 — 0.993 Q28969 →
Q8BJM7 — 0.992 Q8BJM7 →
Q41607 — 0.990 Q41607 →
D3YWQ0 — 0.990 D3YWQ0 →
Q9VUR0 — 0.990 Q9VUR0 →
D3ZKV9 — 0.990 D3ZKV9 →
P03177 — 0.990 P03177 →
A0A0R4IKJ1 — 0.990 A0A0R4IKJ1 →
Q99K23 — 0.990 Q99K23 →
Q1LVQ2 — 0.990 Q1LVQ2 →
A4H7G5 — 0.990 A4H7G5 →
A3KMV1 — 0.990 A3KMV1 →
Q9TUX8 — 0.990 Q9TUX8 →
Q1HVD1 — 0.990 Q1HVD1 →
P54634 — 0.990 P54634 →