Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10986017 | 0.86 | RAB9A (0.41) | EDNRBEDNRAAURKBAURKAKDM4E | |
| SCHEMBL10984243 | 0.83 | CYP1A1 (0.43) | AURKBKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL10924605 | 0.82 | AURKB (0.52) | EDNRBEDNRAAURKBAURKAKDM4E | |
| SCHEMBL10831999 | 0.78 | AURKB (0.43) | EDNRBEDNRAAURKBAURKAKDM4E | |
| SCHEMBL10986778 | 0.73 | KDM4E (0.45) | EDNRBEDNRAAURKBAURKAKDM4E | |
| SCHEMBL10984734 | 0.72 | RAB9A (0.39) | EDNRBEDNRAAURKBAURKAKDM4E | |
| SCHEMBL10977590 | 0.72 | RAB9A (0.39) | EDNRBEDNRAAURKBAURKAKDM4E | |
| SCHEMBL13981827 | 0.71 | PTGS1 (0.69) | KDM4EMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL10989257 | 0.69 | AURKB (0.43) | EDNRBEDNRAAURKBAURKAKDM4E | |
| SCHEMBL10982593 | 0.69 | AURKB (0.43) | EDNRBEDNRAAURKBAURKAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4499279-A | ANTIDIABETIC AND HYPOGLYCEMIC AGENTS | SANDOZ, INC. (US) | 1985-02-12 | — | — | US | disclosed |
| US-4419353-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1983-12-06 | — | — | US | disclosed |
| US-4397850-A | HYPOGLYCEMIC, ANTIDIABETIC | SANDOZ, INC. (US) | 1983-08-09 | — | — | US | disclosed |
| US-4336379-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1982-06-22 | — | — | US | disclosed |