Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | ALPL | P05186 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | F12 | P00748 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | METAP2 | P50579 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4414614 | 0.80 | KMT2A (0.51) | NPC1RAB9ASMN1; SMN2L3MBTL1PKM | |
| SCHEMBL8311607 | 0.77 | KDM4E (0.56) | NPC1RAB9ASMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL18091913 | 0.75 | F2 (0.43) | NPC1RAB9ASMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL14157267 | 0.74 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL6924808 | 0.74 | SMN1; SMN2 (0.47) | NPC1RAB9ASMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL3327100 | 0.74 | KDM4E (0.49) | NPC1RAB9ASMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL19691765 | 0.73 | BTK (0.47) | NPC1RAB9ASMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL19691749 | 0.73 | CBFB (0.49) | NPC1RAB9ASMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL5493272 | 0.72 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL17280240 | 0.71 | SMN1; SMN2 (0.49) | NPC1RAB9ASMN1; SMN2L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4499097-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1985-02-12 | — | — | US | disclosed |
| US-4499097-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1985-02-12 | — | — | US | disclosed |
| US-4499097-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1985-02-12 | — | — | US | disclosed |