Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | METAP1 | P53582 | 6/20 | 0.47 |
| ▸ | METAP2 | P50579 | 5/20 | 0.47 |
| ▸ | CBFB | Q13951 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | ALPL | P05186 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CCR1 | P32246 | 2/20 | 0.46 |
| ▸ | CCR5 | P51681 | 2/20 | 0.46 |
| ▸ | CCR8 | P51685 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311607 | 0.81 | KDM4E (0.56) | KDM4EMETAP1METAP2CBFBNPC1 | |
| SCHEMBL6815366 | 0.80 | CCR1 (0.44) | KDM4EMETAP2CBFBRAB9ASMN1; SMN2 | |
| SCHEMBL6924808 | 0.78 | SMN1; SMN2 (0.47) | KDM4EMETAP1METAP2CBFBNPC1 | |
| SCHEMBL14157267 | 0.78 | NPC1 (0.47) | KDM4EMETAP1METAP2CBFBNPC1 | |
| SCHEMBL28856145 | 0.77 | CCR1 (0.58) | METAP2HSD17B10CCR1CCR8POLB | |
| SCHEMBL5493272 | 0.76 | NPC1 (0.54) | KDM4EMETAP1METAP2NPC1RAB9A | |
| SCHEMBL29908717 | 0.76 | ALDH1A1 (0.30) | SMN1; SMN2 | |
| Pyridine SCHEMBL29135857 | 0.75 | METAP1 (0.48) | KDM4EMETAP1METAP2CBFBNPC1 | |
| SCHEMBL17280240 | 0.75 | SMN1; SMN2 (0.49) | KDM4EMETAP1METAP2CBFBNPC1 | |
| SCHEMBL12469575 | 0.75 | SMN1; SMN2 (0.41) | KDM4EMETAP1METAP2CBFBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1302018-C | [ C N ] type bidentate ligand and post-transition metal coordinated olefin polymerization catalyst and preparation method thereof | UNIV FUDAN (CN) | 2007-02-28 | — | — | CN | claimed |
| CN-107001375-B | 6, 7-dihydropyrazolo [1,5-a ] pyrazin-4 (5H) -one compounds and their use as negative allosteric modulators of MGLUR2 receptors | 詹森药业有限公司 | 2020-06-09 | — | — | CN | disclosed |
| EP-3227295-B1 | 6,7-DIHYDROPYRAZOLO[1,5- ]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLU2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-02-20 | — | — | EP | disclosed |
| US-10072014-B2 | 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one compounds and their use as negative allosteric modulators of MGLUR2 receptors | JANSSEN PHARMACEUTICA NV (BE) | 2018-09-11 | — | — | US | disclosed |
| US-20170369493-A1 | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN-CILAG, S.A. (ES) | 2017-12-28 | — | — | US | disclosed |
| WO-2010054253-A1 | TRIAZINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES | BIOTIE THERAPIES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |
| US-20100120762-A1 | Triazine derivatives as inhibitors of phosphodiesterases | WYETH (US) | 2010-05-13 | — | — | US | disclosed |
| EP-1507785-A4 | TRANSITION METAL COMPLEXES WITH (PYRIDYL)IMIDAZOLE LIGANDS | THERASENSE INC (US) | 2007-12-19 | — | — | EP | disclosed |
| US-20070161681-A1 | ETHER DERIVATIVES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | PFIZER INC. (US) | 2007-07-12 | — | — | US | disclosed |
| US-7183293-B2 | Ether derivatives useful as inhibitors of PDE4 isozymes | PFIZER INC. (US) | 2007-02-27 | — | — | US | disclosed |
| EP-1507785-A2 | TRANSITION METAL COMPLEXES WITH (PYRIDYL)IMIDAZOLE LIGANDS | Therasense, Inc. (US) | 2005-02-23 | — | — | EP | disclosed |
| WO-2004009604-A2 | TRANSITION METAL COMPLEXES WITH (PYRIDYL)IMIDAZOLE LIGANDS | THERASENSE, INC. (US) | 2004-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161681-A1 | ETHER DERIVATIVES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | PDE4A, PDE4B, PDE4D | KDM4E 200/4885METAP1 1626/4885METAP2 1980/4885 |
| US-20170369493-A1 | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | GRM2, GRM5, GRM1 | KDM4E 2069/4885METAP1 4297/4885METAP2 3268/4885 |
| US-10072014-B2 | 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one compounds and their use as negative allosteric modulators of MGLUR2 receptors | GRM2, GRM5, GRM1 | KDM4E 2069/4885METAP1 4297/4885METAP2 3268/4885 |
| US-20100120762-A1 | Triazine derivatives as inhibitors of phosphodiesterases | PDE2A, PDE5A, PDE12 | KDM4E 2470/4885METAP1 1264/4885METAP2 454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.