Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.80 |
| ▸ | PDE2A | O00408 | 1/20 | 0.67 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.56 |
| ▸ | PDE5A | O76074 | 2/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.54 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.54 |
| ▸ | NOS1 | P29475 | 2/20 | 0.51 |
| ▸ | NOS2 | P35228 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | NOS3 | P29474 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11772846 | 0.89 | AURKA (1.00) | AURKAPDE2APRMT5PDE5ATP53 | |
| SCHEMBL10981003 | 0.85 | PDE2A (0.65) | AURKAPDE2APRMT5PDE5AFGFR1 | |
| SCHEMBL7456059 | 0.84 | AURKA (0.64) | AURKAPRMT5PDE5ANPY5RFAAH | |
| SCHEMBL10964336 | 0.80 | AURKA (0.51) | AURKAPDE2ACYP2C9NPY5RTP53 | |
| SCHEMBL11773596 | 0.80 | PDE2A (0.81) | AURKAPDE2APDE5AFGFR1FGFR2 | |
| SCHEMBL11770981 | 0.80 | PDE2A (1.00) | AURKAPDE2APDE5AKDM4EALDH1A1 | |
| SCHEMBL10983075 | 0.80 | AURKA (0.64) | AURKAPDE2APRMT5PDE5ANPY5R | |
| Hydrochloric Acid SCHEMBL11769751 | 0.79 | PDE2A (0.97) | AURKAPDE2APDE5AKDM4EALDH1A1 | |
| SCHEMBL10744129 | 0.79 | AURKA (0.70) | AURKAPDE2APRMT5PDE5AFGFR1 | |
| SCHEMBL7395290 | 0.79 | AURKA (0.64) | AURKAPDE2APDE5AHPSEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4515796-A | INOTROPIC, BRONCHODILATOR, VASODILATORS, ANTICOAGULANTS | ELI LILLY AND COMPANY (US) | 1985-05-07 | — | — | US | disclosed |