Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.70 |
| ▸ | PDE2A | O00408 | 1/20 | 0.57 |
| ▸ | PDE5A | O76074 | 5/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.52 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.51 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11772846 | 0.81 | AURKA (1.00) | AURKAPDE2APDE5APRMT5HPSE | |
| SCHEMBL10744375 | 0.81 | AURKA (0.65) | AURKAPDE2APDE5AFGFR1FGFR2 | |
| SCHEMBL9634492 | 0.80 | AURKA (0.63) | AURKAPDE2APDE5AFGFR1FGFR2 | |
| SCHEMBL712484 | 0.79 | PRMT5 (0.52) | AURKAPDE5APRMT5HPSEALDH1A1 | |
| SCHEMBL10984029 | 0.79 | AURKA (0.80) | AURKAPDE2APDE5AFGFR1FGFR2 | |
| SCHEMBL10266345 | 0.79 | AURKA (0.58) | AURKAPDE2APDE5AFGFR1FGFR2 | |
| SCHEMBL7393911 | 0.78 | AURKA (0.66) | AURKAPDE5APRMT5HPSEMETAP2 | |
| SCHEMBL11775080 | 0.77 | PDE2A (0.72) | AURKAPDE2APDE5AFGFR1FGFR2 | |
| SCHEMBL11771499 | 0.77 | AURKA (0.64) | AURKAPDE2APDE5APRMT5KDM4E | |
| SCHEMBL7395290 | 0.77 | AURKA (0.64) | AURKAPDE2APDE5AHPSEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4696931-A | CARDIOVASCULAR DISORDERS, CARDIOTONIC AGENTS | DR. KARL THOMAE GMBH (DE) | 1987-09-29 | — | — | US | disclosed |
| US-4582837-A | Imidazo[4,5-b] and [4,5-c]pyridine derivatives having cardiotonic activity | DR. KARL THOMAE GMBH (DE) | 1986-04-15 | — | — | US | disclosed |
| EP-0098448-A2 | Imidazole derivatives, their preparation and medicines containing these compounds | Dr. Karl Thomae GmbH (DE) | 1984-01-18 | — | — | EP | disclosed |