Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN4 | Q9Y3Q4 | 6/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | SMPD1 | P17405 | 5/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10986664 | 0.99 | HCN4 (0.72) | HCN4MAPTCYP3A4ALOX15CYP1A2 | |
| SCHEMBL11263213 | 0.97 | HCN4 (0.72) | HCN4MAPTCYP3A4ALOX15CYP1A2 | |
| SCHEMBL10599539 | 0.94 | HCN4 (0.65) | HCN4MAPTCYP3A4ALOX15CYP1A2 | |
| SCHEMBL10979298 | 0.94 | HCN4 (0.75) | HCN4MAPTCYP3A4ALOX15CYP1A2 | |
| SCHEMBL11095646 | 0.93 | HCN4 (0.64) | HCN4MAPTCYP3A4ALOX15CYP1A2 | |
| Hydrochloric Acid SCHEMBL10599369 | 0.93 | HCN4 (0.64) | HCN4MAPTCYP3A4ALOX15CYP1A2 | |
| Hydrochloric Acid SCHEMBL10983829 | 0.92 | HCN4 (0.63) | HCN4MAPTCYP3A4ALOX15CYP1A2 | |
| SCHEMBL11092035 | 0.91 | HCN4 (0.61) | HCN4MAPTCYP3A4ALOX15SMPD1 | |
| Hydrochloric Acid SCHEMBL10984472 | 0.90 | HCN4 (0.60) | HCN4MAPTCYP3A4ALOX15SMPD1 | |
| SCHEMBL11087721 | 0.90 | HCN4 (0.60) | HCN4MAPTCYP3A4ALOX15CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0065229-B1 | BENZAZEPINES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION AS PHARMACEUTICAL PREPARATIONS | Dr. Karl Thomae GmbH (DE) | 1985-08-07 | — | — | EP | disclosed |
| US-4490369-A | HYPOTENSIVE, BRRADYCARDIAL | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-12-25 | — | — | US | disclosed |
| EP-0065229-A1 | Benzazepines, process for their preparation and their application as pharmaceutical preparations | Dr. Karl Thomae GmbH (DE) | 1982-11-24 | — | — | EP | disclosed |