Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 3/20 | 0.66 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11168474 | 1.00 | HTR1B (0.66) | HTR1BMAOBMAOACYP2D6HTR2A | |
| SCHEMBL12967944 | 0.83 | CYP2D6 (0.54) | HTR1BCYP2D6KCNA3KDM4E | |
| SCHEMBL10981487 | 0.82 | HTR1B (0.97) | HTR1BKCNA3KDM4EALDH1A1 | |
| SCHEMBL10993955 | 0.82 | HTR1B (0.97) | HTR1BKCNA3KDM4EALDH1A1 | |
| SCHEMBL10693307 | 0.81 | HTR1B (0.50) | HTR1BMAOBMAOAHTR2AKDM4E | |
| SCHEMBL15473188 | 0.80 | CYP2D6 (0.54) | HTR1BCYP2D6KCNA3 | |
| Hydrochloric Acid SCHEMBL10984513 | 0.80 | HTR1B (0.94) | HTR1BKCNA3KDM4EALDH1A1 | |
| SCHEMBL7275543 | 0.80 | HTR1B (1.00) | HTR1BKCNA3KDM4EALDH1A1 | |
| SCHEMBL12879452 | 0.77 | CYP2D6 (0.56) | CYP2D6KDM4EALDH1A1 | |
| SCHEMBL10694029 | 0.77 | HTR2A (0.49) | HTR1BMAOBMAOAHTR2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4536503-A | Naphthoxyalkylamines and related compounds as antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1985-08-20 | — | — | US | disclosed |
| EP-0082005-A2 | Naphthoxyalkylamines and related compounds, their preparation and antiinflammatory compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1983-06-22 | — | — | EP | disclosed |