SCHEMBL10985669

SCHEMBL10985669

NNc1ccc(Cl)c(Cl)c1Br

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.37
ALDH1A1 P00352 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA9 Q16790 1/20 0.37
MEN1 O00255 2/20 0.35
LMNA P02545 2/20 0.35
POLB P06746 2/20 0.35
KMT2A Q03164 2/20 0.35
NPC1 O15118 1/20 0.35
GAA P10253 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
CXCR1 P25024 1/20 0.34
CXCR2 P25025 1/20 0.34
CYP3A4 P08684 1/20 0.31
MAPK1 P28482 1/20 0.31
KDM4E B2RXH2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10985218 0.82 PTGER4 (0.40) CA1CA2CA9TDP1
SCHEMBL10986649 0.82 MAPT (0.37) MAPTALDH1A1CA1CA2CA9
SCHEMBL10994326 0.78 LMNA (0.36) MAPTALDH1A1CA1CA2CA9
SCHEMBL7554632 0.78 MAPT (0.41) MAPTALDH1A1CA1CA2CA9
Bromide SCHEMBL20984514 0.76 MAPT (0.39) MAPTALDH1A1CA1CA2CA9
Hydrochloric Acid SCHEMBL20984678 0.76 MAPT (0.39) MAPTALDH1A1CA1CA2CA9
SCHEMBL16540069 0.73 LMNA (0.38) MAPTALDH1A1CA1CA2CA9
SCHEMBL31447894 0.73 LMNA (0.38) MAPTALDH1A1CA1CA2CA9
SCHEMBL10988169 0.73 MAPT (0.37) MAPTALDH1A1CA1CA2CA9
SCHEMBL10875349 0.72 CYP3A4 (0.41) LMNATDP1CYP3A4MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0034945-B1 N-PHENYLPYRAZOLE DERIVATIVES MAY & BAKER LIMITED (GB) 1985-08-07 EP disclosed
US-4496390-A WEED-CONTRTOLLING HERBICIDES MAY & BAKER LIMITED (GB) 1985-01-29 US disclosed
EP-0034945-A2 N-phenylpyrazole derivatives MAY & BAKER LIMITED (GB) 1981-09-02 EP disclosed