Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 10/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 10/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.34 |
| ▸ | CDK2 | P24941 | 6/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797578 | 0.78 | CDK5 (0.37) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL8796670 | 0.77 | HDAC1 (0.40) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL20557462 | 0.76 | CDK5 (0.43) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL6741408 | 0.70 | CDK5 (0.35) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL22031127 | 0.68 | CDK5 (0.44) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL7332982 | 0.68 | CDK5 (0.58) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL10702053 | 0.68 | SMN1; SMN2 (0.42) | — | |
| Hydrochloric Acid SCHEMBL10703604 | 0.67 | SMN1; SMN2 (0.41) | — | |
| SCHEMBL8686075 | 0.67 | CDK5 (0.38) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL6233700 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4492794-A | 2-Guanidino-4-hydroxymethylthiazole and derivatives thereof | SHIONOGI & CO., LTD. (JP) | 1985-01-08 | — | — | US | disclosed |
| EP-0123741-A1 | 2-Guanidino-4-hydroxymethylthiazole and derivatives thereof | SHIONOGI & CO., LTD. (JP) | 1984-11-07 | — | — | EP | disclosed |