Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10986180 | 0.93 | GRIN2B (0.43) | SMN1; SMN2NPC1RAB9APSEN1PSEN2 | |
| SCHEMBL10992885 | 0.90 | SMN1; SMN2 (0.39) | SMN1; SMN2NPC1RAB9APSEN1PSEN2 | |
| SCHEMBL10987242 | 0.89 | NPC1 (0.45) | SMN1; SMN2NPC1RAB9APSEN1PSEN2 | |
| SCHEMBL11231397 | 0.88 | RAB9A (0.44) | SMN1; SMN2NPC1RAB9APSEN1PSEN2 | |
| SCHEMBL200902 | 0.88 | PREP (0.44) | SMN1; SMN2NPC1RAB9APSEN1PSEN2 | |
| SCHEMBL10991366 | 0.87 | HSD17B10 (0.43) | SMN1; SMN2NPC1RAB9APSEN1PSEN2 | |
| SCHEMBL10985753 | 0.87 | PREP (0.42) | SMN1; SMN2NPC1RAB9APSEN1PSEN2 | |
| SCHEMBL10989802 | 0.86 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9APSEN1PSEN2 | |
| SCHEMBL10984991 | 0.86 | NPC1 (0.43) | SMN1; SMN2NPC1RAB9APSEN1PSEN2 | |
| SCHEMBL10987961 | 0.86 | ELANE (0.44) | SMN1; SMN2NPC1RAB9APSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4499287-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1985-02-12 | — | — | US | disclosed |
| US-4456761-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1984-06-26 | — | — | US | disclosed |
| US-4356182-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-10-26 | — | — | US | disclosed |
| US-4291040-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1981-09-22 | — | — | US | disclosed |